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Keywords: Trypanosoma
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Journal Articles
J Cell Sci jcs.261692.
Published: 4 April 2024
... genome-wide analysis, we have identified 30 transition fibre proteins (TFPs) and mapped their arrangement in the flagellated eukaryote Trypanosoma brucei . We discovered TFPs are recruited to the mature basal body pre- and post-basal body duplication with differential expression of TFPs at the assembling...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and flagella
J Cell Sci (2019) 132 (16): jcs231795.
Published: 15 August 2019
... the light path is split to visualise multiple focal planes simultaneously, was used to reconstruct Trypanosoma brucei and Leishmania mexicana movement in 3D. These species are uniflagellate unicellular parasites for which motility is vital. It was possible to use either a fluorescent stain or a genetically...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (8): 1379–1392.
Published: 15 April 2017
... comprehensive trypanosome clathrin interactome to date. We identified the trypanosome AP-1 complex, Trypanosoma brucei (Tb)EpsinR, several endosomal SNAREs plus orthologues of SMAP and the AP-2 associated kinase AAK1 as interacting with clathrin. Novel lineage-specific proteins were identified, which we...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (8): 1421–1434.
Published: 15 April 2017
... Euglenozoa genomes. Bodonids possess a large trafficking repertoire, which is mainly retained by the Trypanosoma cruzi group, with extensive losses in other lineages, particularly African trypanosomes and phytomonads. There are no large-scale expansions or contractions from an inferred ancestor, excluding...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2009) 122 (6): 859–866.
Published: 15 March 2009
.... Cell Dev. Biol. 14 , 111 -136. Brown, D. A. and London, E. ( 2000 ). Structure and function of sphingolipid- and cholesterol-rich membrane rafts. J. Biol. Chem. 275 , 17221 -17224. Coppens, I. and Courtoy, P. J. ( 2000 ). The adaptative mechanisms of Trypanosoma brucei for sterol...
Journal Articles
J Cell Sci (2009) 122 (6): 867–874.
Published: 15 March 2009
...@northwestern.edu ) 17 11 2008 © The Company of Biologists Limited 2009 2009 Flagellum Palmitoylation Membrane microdomains Acylation Trypanosoma Protein palmitoylation is the thioester linkage of long chain fatty acids, most commonly palmitic acid, to cysteine residues of protein...
Journal Articles
In collection:
Lipid biology
J Cell Sci (2008) 121 (4): 522–535.
Published: 15 February 2008
...; however, recent studies in trypanosomes point to the dispensability of sphingolipids in some of these processes. In this study, we explore the requirements for de novo sphingolipid biosynthesis in the insect life cycle stage of the African trypanosome Trypanosoma brucei by inhibiting the enzyme serine...
Includes: Multimedia, Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2005) 118 (4): 831–841.
Published: 15 February 2005
...Helen P. Price; Chrysoula Panethymitaki; David Goulding; Deborah F. Smith Myristoyl-CoA:protein N -myristoyltransferase (NMT), an essential protein in Trypanosoma brucei and Leishmania major , catalyses the covalent attachment of the fatty acid myristate to the N-terminus of a range of target...
Includes: Supplementary data
Journal Articles
In collection:
Metabolism
J Cell Sci (2002) 115 (13): 2651–2658.
Published: 1 July 2002
... of yeasts and mammals. The PEX2 gene of Trypanosoma brucei was identified and its expression was silenced by means of tetracycline-inducible RNA interference. Bloodstream-form trypanosomes, which rely exclusively on glycolysis for ATP generation, died rapidly upon PEX2 depletion. Insect-form (procyclic...
Journal Articles