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Keywords: Transport
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Journal Articles
J Cell Sci (2021) 134 (21): jcs240523.
Published: 4 November 2021
...Svetlana Lutsenko ABSTRACT Copper (Cu) homeostasis is essential for the development and function of many organisms. In humans, Cu misbalance causes serious pathologies and has been observed in a growing number of diseases. This Review focuses on mammalian Cu(I) transporters and highlights recent...
Journal Articles
J Cell Sci (2021) 134 (15): jcs258776.
Published: 3 August 2021
...Jessica J. A. Hummel; Casper C. Hoogenraad ABSTRACT Molecular motors drive long-range intracellular transport of various vesicles and other cargoes within a cell. Identifying which kinesin motors interact with which type of transport vesicles has been challenging, especially in complex neuronal...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and flagella
J Cell Sci (2021) 134 (12): jcs247163.
Published: 14 June 2021
...Mareike A. Jordan; Gaia Pigino ABSTRACT The intraflagellar transport (IFT) system is a remarkable molecular machine used by cells to assemble and maintain the cilium, a long organelle extending from eukaryotic cells that gives rise to motility, sensing and signaling. IFT plays a critical role...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
J Cell Sci (2016) 129 (18): 3499–3510.
Published: 15 September 2016
... by kinesin-1 sorting in axons that differentially controls stability of arbor terminals. We also assessed the possibility that selective kinesin-1 transport directly correlates with microtubule stability in the terminal segments. In this experiment, FRAP was applied to CGN axons that simultaneously...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
J Cell Sci (2016) 129 (18): 3499–3510.
Published: 15 September 2016
... of Biologists Ltd 2016 Summary: Axonal transport of kinesin-1 and microtubule dynamics are differentially regulated between terminals in a single axon, and contribute to shaping the axonal arbor by differentially regulating retraction of terminals. Axon Retraction Transport Kinesin Microtubule...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (3): 423–429.
Published: 1 February 2015
...Greg Kabachinski; Thomas U. Schwartz ABSTRACT Nuclear pore complexes (NPCs) are indispensable for cell function and are at the center of several human diseases. NPCs provide access to the nucleus and regulate the transport of proteins and RNA across the nuclear envelope. They are aqueous channels...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (1): 124–136.
Published: 1 January 2014
...-glycine). These are ‘intrinsically disordered’ and often represent weak interaction sites that become ordered upon interaction. We investigated this possibility during nuclear transport. Using electron microscopy of S. cerevisiae , we show that NPC cytoplasmic filaments form a dome-shaped structure...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (11): 2319–2329.
Published: 1 June 2013
...Mariella A. M. Franker; Casper C. Hoogenraad Summary Microtubule-based transport is essential for neuronal function because of the large distances that must be traveled by various building blocks and cellular materials. Recent studies in various model systems have unraveled several regulatory...
Journal Articles
J Cell Sci (2013) 126 (3): 705–713.
Published: 1 February 2013
... Microtubule Cytoskeleton Motor protein Dynein Transport ATPases associated with various activities (AAA+) The size of eukaryotic cells and the crowded nature of their cytoplasm mean that they rely on motor proteins to move components around. There are three families of cytoskeletal motor proteins...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (11): 2615–2625.
Published: 1 June 2012
... with drugs, we found that two independent modifications of E-cadherin inhibit its cell surface transport. First, O-linked β-N-acetylglucosamine (O-GlcNAc) modification of the cytoplasmic domain retains E-cadherin in the endoplasmic reticulum. Second, incomplete processing by proprotein convertases arrests E...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (6): 978–987.
Published: 15 March 2011
... an approach in which we deplete the Golgi complex from living cells by laser nanosurgery, and subsequently analyze the ‘Golgi-depleted’ karyoplast using time-lapse and electron microscopy. We show that biosynthetic transport is blocked after Golgi depletion, but is restored 12 hours later. This recovery...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2009) 122 (16): 2914–2923.
Published: 15 August 2009
...Lynne Chang; Kari Barlan; Ying-Hao Chou; Boris Grin; Margot Lakonishok; Anna S. Serpinskaya; Dale K. Shumaker; Harald Herrmann; Vladimir I. Gelfand; Robert D. Goldman Intermediate filament (IF) dynamics during organelle transport and their role in organelle movement were studied using Xenopus...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2008) 121 (22): 3834–3841.
Published: 15 November 2008
... binding interactions with the spindle yielded data for headless and full-length Ncd that did not fit well to previous recovery models. We report a new model that accounts for Ncd transport towards the equator revealed by fluorescence flow analysis of early mitotic spindles and gives rate constants...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2007) 120 (24): 4395–4406.
Published: 15 December 2007
... of Biologists Limited 2007 2007 Cadherin Catenin Lysosome Trans-Golgi Transport Cadherins are a family of cell-surface glycoproteins that mediate Ca 2+ -dependent cell-cell adhesion in tissues ( Takeichi, 1988 ). E-cadherin, a prototypical member of this family, is required...
Journal Articles
J Cell Sci (2007) 120 (14): 2454–2466.
Published: 15 July 2007
... of TGFα family proteins. Human CNIH complements the loss of Erv14 in yeast. Human CNIH and Drosophila Cni are primarily localized in the endoplasmic reticulum and associate with immature TGFα family proteins. Alterations of cornichon expression result in changes in transport, processing and secretion...
Journal Articles
J Cell Sci (2006) 119 (8): 1612–1621.
Published: 15 April 2006
... with an adenoviral vector expressing a mutated α1 subunit, resulting in a dominant-negative effect on endogenous AMPK activity. These effects are blocked by 5′-iodotubercidine (5′-ITU), an inhibitor of adenosine kinase. Moreover, inhibition of adenosine transport through the concentrative adenosine plasma membrane...
Journal Articles
J Cell Sci (2005) 118 (12): 2661–2670.
Published: 15 June 2005
... the association of endosomes to actin cables preventing their transport to the cell centre. * Author for correspondence (e-mail: m.fernandez@sanquin.nl ) 16 3 2005 © The Company of Biologists Limited 2005 2005 RhoB Dia1 Endocytosis Transport Cell morphological changes...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2004) 117 (24): 5923–5936.
Published: 15 November 2004
... tested nuclear translocation mechanisms in electroporated HeLa cells, rat cortical neurons and glial cells using novel calmodulin and inhibitor peptide probes and confocal microscopy. Passive diffusion of calmodulin across the nuclear membrane was measured in conditions in which facilitated transport...
Journal Articles
Journal Articles
J Cell Sci (2004) 117 (3): 381–388.
Published: 22 January 2004
...Vladimir Sytnyk; Iryna Leshchyns'ka; Alexander Dityatev; Melitta Schachner Synapse formation, stabilization and maintenance comprise several remarkably precise and rapid stages. The initial steps involve delivery to the site of initial contact between axon and dendrite of transport carriers...