..., including rolling, adhesion, crawling, diapedesis and sub-endothelial crawling. Nowadays, the role of the endothelium in transmigration is increasingly appreciated. It has been established that leukocyte exit sites on the endothelium and in the pericyte layer are in fact not random but instead may...

...-selectin in regulating neutrophil TEM. References Allport , J. R. , Ding , H. , Collins , T. , Gerritsen , M. E. and Luscinskas , F. W. ( 1997a ). Endothelial-dependent mechanisms regulate leukocyte transmigration: a process involving the proteasome and disruption...

... within transmigrated pseudopods re-establishes their binding to targets, such as L-selectin. Knockdown of ezrin, but not moesin, severely impaired the recruitment of monocytes to activated endothelial monolayers under flow, suggesting that this protein plays a unique role in the early recruitment process...

... cell stiffness and its relevance for leukocyte adhesion, crawling and transendothelial migration. Adhesion Endothelium ICAM1 Mechanotransduction Transmigration Single-cell organisms, circulating cells and cells in tissues respond to a wide range of stimuli with polarization...

... and the endothelium. Leukocyte β2-integrins bind to endothelial intercellular adhesion molecule 1 (ICAM-1), which allows leukocyte spreading, crawling and transendothelial migration. Leukocytes scan the vascular endothelium for permissive sites to transmigrate, which suggests that there is apical membrane...

... in ECs was also involved in monocyte transmigration. Collectively, our study identifies a role of EphBR-ephrinB interactions as a new step in the cascade of events leading to monocyte adhesion and transmigration through the vascular endothelium. * Author for correspondence (e-mail: augustin...

.... Using mixed cultures of wild-type and PrP C -deficient mouse brain endothelial cells, we observed that PrP C accumulation at cell-cell contacts was probably dependent on homophilic interactions between adjacent cells. Moreover, we report that anti-PrP C antibodies unexpectedly inhibited transmigration...

... intracellular stores to the cell surface of transmigrating mouse neutrophils, although these events occur via mechanisms dependent on and independent of platelet/endothelial-cell adhesion molecule 1 (PECAM-1, CD31), respectively. Despite different regulatory mechanisms, blockade of α6 integrins or NE inhibited...

... Permeability Transmigration Homotypic cell-cell adhesion between epithelial or endothelial cells is mediated by adhesion structures such as adherens junctions, tight junctions and desmosomes. Members of the cadherin family of calcium-dependent homotypic cell-cell adhesion molecules are largely...

... Zurich, Switzerland 12 02 1990 25 04 1990 © 1990 by Company of Biologists 1990 neutrophils adherence transmigration thrombin endothelium With respect to the steadily growing knowledge on highly specific functions of the endothelial cell lining, the ability...