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Keywords: Transmembrane domain
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Journal Articles
J Cell Sci (2020) 133 (17): jcs231423.
Published: 1 September 2020
...Wim Annaert; Christoph Kaether ABSTRACT The quote “bring it back, bring it back, don't take it away from me” from Queen's Love of my life describes the function of the sorting receptor RER1, a 23 kDa protein with four transmembrane domains (TMDs) that localizes to the intermediate compartment...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (21): jcs220830.
Published: 5 November 2018
...Alexandre Vernay; Otmane Lamrabet; Jackie Perrin; Pierre Cosson ABSTRACT Previous studies have shown that TM9SF4 interacts with glycine-rich transmembrane domains (TMDs) and promotes their surface localization, presumably by escorting them along the secretory pathway. Here, we delineated the role...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (22): 3829–3838.
Published: 15 November 2017
... by recycling to the plasma membrane results in a polarised distribution of membrane proteins by a kinetic mechanism. Here, we report that increasing the volume of residues that constitute the exoplasmic half of the transmembrane domain (TMD) in the yeast SNARE Sso1, a type II membrane protein, results in its...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (1): 95–107.
Published: 1 January 2016
...Tomáš Chum; Daniela Glatzová; Zuzana Kvíčalová; Jan Malínský; Tomáš Brdička; Marek Cebecauer ABSTRACT Plasma membrane proteins synthesised at the endoplasmic reticulum are delivered to the cell surface via sorting pathways. Hydrophobic mismatch theory based on the length of the transmembrane domain...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (13): 2269–2277.
Published: 1 July 2015
... such as the Dictyostelium SibA protein. Here, we show that the glycine-rich transmembrane domain (TMD) of SibA is sufficient to confer Phg1A-dependent surface targeting to a reporter protein. Accordingly, in Dictyostelium phg1A -knockout (KO) cells, proteins with glycine-rich TMDs were less efficiently transported out...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (23): 5344–5349.
Published: 1 December 2013
... analyses on a large number of single-spanning membrane proteins support the hypothesis that specific features of the transmembrane domain (TMD) are relevant to the sorting of these proteins to particular organelles. Here we experimentally test this hypothesis for Golgi and plasma membrane proteins. Using...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (21): 4900–4912.
Published: 1 November 2013
... dimerization motif in the transmembrane domain (TMD) for clustering-induced internalization. Moreover, conventional EGF-induced receptor internalization depends exclusively on this TMD dimerization and kinase activity. Mutations in this dimerization motif eventually lead to reduced EGFR degradation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (14): 2473–2480.
Published: 15 July 2010
... membrane proteins syntaxin-1A and SNAP-25. Although clearly important at the point of membrane fusion, the precise structural and functional requirements for the transmembrane domains (TMDs) of SNAREs in bringing about neurosecretion remain largely unknown. Here, we used a bimolecular fluorescence...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (11): 1759–1767.
Published: 1 June 2009
...Anna Dukhovny; Yakey Yaffe; Jeanne Shepshelovitch; Koret Hirschberg The cellular destination of secretory proteins is determined by interactions of their targeting motifs with coat-protein complexes. The transmembrane domain (TMD) of secretory proteins also plays a central role in their transport...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2008) 121 (20): 3373–3382.
Published: 15 October 2008
..., anywhere from one to five GFP-positive cells per animals were suitable for imaging. © The Company of Biologists Limited 2008 2008 Bcl-2 BCL2 CED-9 DRP-1 Mitochondria Morphology Dynamics Homeostasis C. elegans Transmembrane domain Bcl-2 proteins regulate apoptosis through...
Includes: Supplementary data
Journal Articles
J Cell Sci (2002) 115 (8): 1689–1702.
Published: 15 April 2002
...Alessandra Bulbarelli; Teresa Sprocati; Massimo Barberi; Emanuela Pedrazzini; Nica Borgese Tail-anchored (TA) proteins, which are defined by an N-terminal cytosolic region and a C-terminal transmembrane domain (TMD), provide useful models for studying the role of the TMD in sorting within the exo...
Journal Articles
J Cell Sci (2001) 114 (17): 3115–3124.
Published: 1 September 2001
... localization pattern. However, the signals that drive the specific intracellular localization of syntaxins are poorly understood. In this study, we used indirect immunofluorescence analysis to examine the localization of syntaxin chimeras, each containing a syntaxin transmembrane domain fused to a cytoplasmic...