... identifying non-transcriptional mechanisms crucial to regulating the core mammalian clock proteins and their role in circadian rhythmicity. Circadian rhythm Post-transcriptional modification Post-translational modification Translational regulation Cellular timekeeping We live in a 24-h world...

... Translational regulation Puf protein RNA-binding protein Ribosomal biogenesis Translational control of gene expression plays an important role during the development of eukaryotes. This regulation is often mediated by cis -acting elements in the 3′ untranslated region (UTR) of the mRNA. Binding...

..., the experiments in primary oligodendrocytes and the reporter assays in Oli- neu cells suggest that active Fyn induces the translation of Mobp mRNAs containing an A2RE in their 3′UTR. Fig. 4. Fyn-mediated translational regulation of A2RE-containing MOBP reporter constructs. Oli- neu cells were co...

..., translational and post-translational regulation. This Commentary discusses the latest understandings and insights into the underlying molecular mechanisms, and presents the perspectives necessary to enable our system-level understanding of leaf senescence, together with their possible implications for aging...

... a functional diversification of the enzymatic class of deadenylases. * Author for correspondence ( eckmann@mpi-cbg.de ) 12 06 2013 © 2013. Published by The Company of Biologists Ltd 2013 Germline development Poly(A) metabolism Deadenylase Translational regulation...

... is required for translational repression of several maternal mRNAs in the distal gonad and functions in conjunction with the broad-scale translational regulators CGH-1, CAR-1 and PATR-1 to regulate germ cell sex determination. Furthermore we have found that IFET-1 localizes to P granules throughout the gonad...

... and chloroplasts would certainly help in understanding the differential requirements of this protein and its effect on translation regulation. According to the scanning model, translation is initiated at the first AUG codon contained in a particular context ( Kozak, 1991 ). Why would translation initiation...

...Hideyuki Okano; Takao Imai; Masataka Okabe Transcription is thought to have a major role in the regulation of cell fate; the importance of translational regulation in this process has been less certain. Recent findings demonstrate that translational regulation contributes to cell-fate specification...