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Keywords: Translation
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Journal Articles
J Cell Sci (2022) 135 (23): jcs260388.
Published: 7 December 2022
... of ORBs in translation quality control of non-translatable defective mRNAs with arrested ribosomes. By contrast, translation granules are sites of active translation, Not1-containing assemblysomes contain temporarily paused ribosomes, and P-bodies and stress granules handle translationally repressed mRNAs...
Includes: Supplementary data
Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2022) 135 (19): jcs259856.
Published: 6 October 2022
... regulated. We identify the methyltransferase SETD2 as a negative regulator of global protein synthesis rates and cell size. SETD2 Histone methyltransferase Translation Cell size Nederlandse Organisatie voor Wetenschappelijk Onderzoek http://dx.doi.org/10.13039/501100003246 NWO-VICI...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (14): jcs259629.
Published: 26 July 2022
.... , Evdokimova , V. et al. ( 2015 ). YB-1 regulates stress granule formation and tumor progression by translationally activating G3BP1 . J. Cell Biol. 208 , 913 - 929 . 10.1083/jcb.201411047 Sonenberg , N. and Hinnebusch , A. G. ( 2009 ). Regulation of translation initiation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (18): jcs258643.
Published: 27 September 2021
... of Col1a1 mRNA. Translation of collagen polypeptides occurs in the ER, where the polypeptide chains are translationally and post-translationally modified to form the triple helix ( Malhotra and Erlmann, 2015 ; Sharma et al., 2017 ; Zhang and Stefanovic, 2016 ). To examine the effects...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (11): jcs258338.
Published: 4 June 2021
... including protein biosynthesis and transcription, and dedicated follow-up experiments highlight the importance of accurate transcriptional and translational control for mitigating protein aggregation and toxicity during arsenite stress. Some of the hits are associated with pathological conditions...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (1): jcs248476.
Published: 13 January 2021
... synthesis is an intricate process governed by upstream signalling pathways. Eukaryotic translation is a multistep process and can be separated into four distinct phases: initiation, elongation, termination and recycling of ribosomal subunits. Translation initiation, the focus of this article, is highly...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (22): jcs251983.
Published: 27 November 2020
... from consequences of defects in membrane proteins, quality control systems act to maintain protein homeostasis. The majority of these pathways act post-translationally; however, recent evidence reveals that membrane proteins are also subject to co-translational quality control during their synthesis...
Journal Articles
J Cell Sci (2020) 133 (5): jcs238014.
Published: 5 March 2020
... synthesis. To determine the mechanism of translational regulation, we assessed the proportions of ribosomes engaged in polysomes ( Fig. 3 F,G) and the relative amounts of translationally active polysome-associated transcripts ( Fig. S3G ). In resting T cells, about 50% of ribosomes are engaged...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (12): jcs228908.
Published: 19 June 2019
.... By contrast, many 5′UTRs of the dicot plant A. thaliana harbor long poly(A) stretches ( Guo et al., 2016 ). Moreover, A-rich sequence motifs were recently identified in the 5′ leaders of a motif containing almost exclusively purines (R-motif) in translationally upregulated mRNAs during A. thaliana...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (12): jcs229252.
Published: 17 June 2019
... granules. Knockdown of OTUD4 in HeLa cells resulted in defects in stress granule formation and led to apoptotic cell death. Together, we characterize OTUD4 as a new RNA-binding protein with a suggested function in regulation of translation. Several of our results hint towards an involvement of OTUD4...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (2): jcs224055.
Published: 18 January 2019
... transcripts in dendrites has suggested that synapses could be modified directly through regulation of local protein synthesis ( Bramham and Wells, 2007 ; Sutton and Schuman, 2006 ). It is thought that synaptic mRNAs are transported in a translationally dormant state via interactions with RNA-binding proteins...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (19): jcs220244.
Published: 5 October 2018
... defined SGs are composed of translation initiation factors, 40S ribosomes, RNA-binding proteins and poly(A) + mRNAs. As such, they represent an important compartment for storage of mRNAs and regulation of their translation. Emerging work on SGs indicates that these structures might promote cellular...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (17): jcs220327.
Published: 3 September 2018
...Vilte Stonyte; Erik Boye; Beáta Grallert ABSTRACT It is generally accepted that global translation varies during the cell cycle and is low during mitosis. However, addressing this issue is challenging because it involves cell synchronization, which evokes stress responses that, in turn, affect...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
J Cell Sci (2018) 131 (9): jcs216176.
Published: 4 May 2018
... and translationally inactive state ( Buxbaum et al., 2014 ). Recent work has shown that localized mRNAs are co-transported with membranous compartments, such as those of the ER ( Jansen et al., 2014 ; Schmid et al., 2006 ). Since the translation of membrane and secreted proteins occurs at the rough ER...
Includes: Supplementary data
Journal Articles
In collection:
Mitochondria
J Cell Sci (2017) 130 (24): 4193–4199.
Published: 15 December 2017
... non-canonical amino acid labelling and click chemistry. This allows visualisation of the translational output in different mitochondria within a cell, their position within that cell and a comparison of mitochondrial translation between cells. The most highly translationally active mitochondria were...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (24): 4534–4547.
Published: 15 December 2016
... with the cloverleaf structure of the EV71 RNA 5′UTR to inhibit viral RNA transcription, and binds to the internal ribosome entry site (IRES) of the EV71 5′UTR to attenuate viral RNA translation. Thus, EV71 stimulates SIRT1 production and activity, which in turn represses EV71 genome replication by inhibiting viral...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (12): 2407–2415.
Published: 15 June 2016
...Jirapas Jongjitwimol; Robert A. Baldock; Simon J. Morley; Felicity Z. Watts ABSTRACT Regulation of protein synthesis is crucial for cells to maintain viability and to prevent unscheduled proliferation that could lead to tumorigenesis. Exposure to stress results in stalling of translation, with many...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (3): 492–501.
Published: 1 February 2016
... of spermatocytes and spermatids ( Paronetto and Sette, 2010 ; Nguyen-Chi and Morello, 2011 ; Idler and Yan, 2012 ; Kleene, 2013 ). Many mRNA transcribed in spermatocytes and round spermatids are stored in a translationally inactive state for several days to more than two weeks, before their protein products can...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (23): 4420–4427.
Published: 1 December 2015
...Jon Halvor Jonsrud Knutsen; Gro Elise Rødland; Cathrine Arnason Bøe; Tine Weise Håland; Per Sunnerhagen; Beáta Grallert; Erik Boye ABSTRACT Exposure of fission yeast cells to ultraviolet (UV) light leads to inhibition of translation and phosphorylation of the eukaryotic initiation factor-2α (eIF2α...
Journal Articles
J Cell Sci (2015) 128 (14): 2497–2508.
Published: 15 July 2015
... - and Sin1 -depleted cells ( Fig. 4 C,D). This confirms that the loss of TORC2 function does not modulate HSP83 and HSP70 levels. Taken together, our results show that the heat-shock response of transcriptionally and translationally upregulating the HSP level is not modulated by TORC2. In fact, the HSPs...
Includes: Supplementary data