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Keywords: Translation
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Journal Articles
J Cell Sci (2021) 134 (18): jcs258643.
Published: 27 September 2021
... <0.001. Translation of collagen polypeptides occurs in the ER, where the polypeptide chains are translationally and post-translationally modified to form the triple helix ( Malhotra and Erlmann, 2015 ; Sharma et al., 2017 ; Zhang and Stefanovic, 2016 ). To examine the effects of hypusinated...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (11): jcs258338.
Published: 04 June 2021
... including protein biosynthesis and transcription, and dedicated follow-up experiments highlight the importance of accurate transcriptional and translational control for mitigating protein aggregation and toxicity during arsenite stress. Some of the hits are associated with pathological conditions...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (1): jcs248476.
Published: 13 January 2021
... synthesis is an intricate process governed by upstream signalling pathways. Eukaryotic translation is a multistep process and can be separated into four distinct phases: initiation, elongation, termination and recycling of ribosomal subunits. Translation initiation, the focus of this article, is highly...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (22): jcs251983.
Published: 27 November 2020
... from consequences of defects in membrane proteins, quality control systems act to maintain protein homeostasis. The majority of these pathways act post-translationally; however, recent evidence reveals that membrane proteins are also subject to co-translational quality control during their synthesis...
Journal Articles
J Cell Sci (2020) 133 (5): jcs238014.
Published: 05 March 2020
.... Activation-induced gains in fluorescence were also observed in naïve and CD4 + T cells from the Lifeact-EGFP reporter, and were readily detected by both flow cytometry and live cell microscopy. This unique, translationally controlled reporter of effector T cell activation simultaneously enables tracking...
Journal Articles
J Cell Sci (2019) 132 (12): jcs228908.
Published: 19 June 2019
...., 2016 ). Once the 40S subunit identifies a start codon it is joined by a 60S subunit to form a translationally competent 80S ribosome that can begin decoding the mRNA open reading frame (ORF). Although each step is regulated by several eukaryotic initiation factors (eIFs) to control translation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (12): jcs229252.
Published: 17 June 2019
... granules. Knockdown of OTUD4 in HeLa cells resulted in defects in stress granule formation and led to apoptotic cell death. Together, we characterize OTUD4 as a new RNA-binding protein with a suggested function in regulation of translation. OTUD4 granules showed movements in anterograde and retrograde...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (2): jcs224055.
Published: 18 January 2019
... synthesis ( Bramham and Wells, 2007 ; Sutton and Schuman, 2006 ). It is thought that synaptic mRNAs are transported in a translationally dormant state via interactions with RNA-binding proteins. Following synaptic stimulation, local mRNA translation is then activated in the synaptic region by neutralizing...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (19): jcs220244.
Published: 05 October 2018
... defined SGs are composed of translation initiation factors, 40S ribosomes, RNA-binding proteins and poly(A) + mRNAs. As such, they represent an important compartment for storage of mRNAs and regulation of their translation. Emerging work on SGs indicates that these structures might promote cellular...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (17): jcs220327.
Published: 03 September 2018
...Vilte Stonyte; Erik Boye; Beáta Grallert ABSTRACT It is generally accepted that global translation varies during the cell cycle and is low during mitosis. However, addressing this issue is challenging because it involves cell synchronization, which evokes stress responses that, in turn, affect...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
J Cell Sci (2018) 131 (9): jcs216176.
Published: 04 May 2018
..., persistence and information transmission during signal relay and collective migration . J. Cell Sci.   123 , 1724 - 1731 . 10.1242/jcs.060137 Mollet , S. , Cougot , N. , Wilczynska , A. , Dautry , F. , Kress , M. , Bertrand , E. and Weil , D. ( 2008 ). Translationally...
Includes: Supplementary data
Journal Articles
In collection:
Mitochondria
J Cell Sci (2017) 130 (24): 4193–4199.
Published: 15 December 2017
... non-canonical amino acid labelling and click chemistry. This allows visualisation of the translational output in different mitochondria within a cell, their position within that cell and a comparison of mitochondrial translation between cells. The most highly translationally active mitochondria were...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (24): 4534–4547.
Published: 15 December 2016
... with the cloverleaf structure of the EV71 RNA 5′UTR to inhibit viral RNA transcription, and binds to the internal ribosome entry site (IRES) of the EV71 5′UTR to attenuate viral RNA translation. Thus, EV71 stimulates SIRT1 production and activity, which in turn represses EV71 genome replication by inhibiting viral...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (12): 2407–2415.
Published: 15 June 2016
...Jirapas Jongjitwimol; Robert A. Baldock; Simon J. Morley; Felicity Z. Watts ABSTRACT Regulation of protein synthesis is crucial for cells to maintain viability and to prevent unscheduled proliferation that could lead to tumorigenesis. Exposure to stress results in stalling of translation, with many...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (3): 492–501.
Published: 01 February 2016
... of spermatocytes and spermatids ( Paronetto and Sette, 2010 ; Nguyen-Chi and Morello, 2011 ; Idler and Yan, 2012 ; Kleene, 2013 ). Many mRNA transcribed in spermatocytes and round spermatids are stored in a translationally inactive state for several days to more than two weeks, before their protein products can...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (23): 4420–4427.
Published: 01 December 2015
...Jon Halvor Jonsrud Knutsen; Gro Elise Rødland; Cathrine Arnason Bøe; Tine Weise Håland; Per Sunnerhagen; Beáta Grallert; Erik Boye ABSTRACT Exposure of fission yeast cells to ultraviolet (UV) light leads to inhibition of translation and phosphorylation of the eukaryotic initiation factor-2α (eIF2α...
Journal Articles
J Cell Sci (2015) 128 (14): 2497–2508.
Published: 15 July 2015
... of heat-shock proteins. Instead, we show, both in vivo and in cultured cells, that TORC2 is required for the assembly of heat-induced cytoprotective ribonucleoprotein particles, the pro-survival stress granules. These granules are formed in response to protein translation inhibition imposed by heat stress...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (9): 1992–2004.
Published: 01 May 2014
... into the Dcp2-positive foci in Δscp160 cells. In either Δbfr1 or Δscp160 cells, P body formation was uncoupled from translational attenuation as the polysome profile remained unchanged. Collectively, our data suggest that Bfr1 and Scp160 prevent P body formation under normal growth conditions. Antibodies...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (19): 4331–4338.
Published: 01 October 2013
... that are used to monitor or count mitochondrial abundance are not known, nor are the signalling pathways. Inhibiting the translation on mito-ribosomes genetically or with antibiotics can impair cell proliferation and has been attributed to defects in aerobic energy metabolism, even though proliferating cells...
Journal Articles
J Cell Sci (2012) 125 (21): 5221–5232.
Published: 01 November 2012
.... , Campbell   S. G. , Holmes   L. E. , Ashe   M. P. ( 2007 ). Stress-dependent relocalization of translationally primed mRNPs to cytoplasmic granules that are kinetically and spatially distinct from P-bodies.   J. Cell Biol.   179 , 65 – 74 . 10.1083/jcb.200707010 Huh   W. K. , Falvo...
Includes: Supplementary data