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Keywords: Translation
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Journal Articles
J Cell Sci (2023) 136 (10): jcs260631.
Published: 18 May 2023
... biogenesis ( Lubas et al., 2018 ). Interestingly, in B cells, the polyamine spermidine post-translationally modifies EIF5A by adding the unusual amino acid hypusine ( Zhang et al., 2019a ). Hypusinated EIF5A is required for the translation of hard-to-read motifs and is also important for the translation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2023) 136 (4): jcs260496.
Published: 21 February 2023
... irregularly shaped nucleolus. These morphological alterations are consistent with changes to nucleolar phase separation properties. Re-organization of the nucleolar structure was correlated with enhanced rRNA production and protein translation. Inhibition of mTOR signaling with rapamycin perturbed nucleolar...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (23): jcs260388.
Published: 7 December 2022
... experiments. Scale bars: 2 µm. If ORBs compartmentalize translation quality control, they should be enriched in a translationally arrested RNC, a translation quality control-specific substrate ( Brandman et al., 2012 ; Navickas et al., 2020 ). An arrested RNC was generated on a URA3 mRNA...
Includes: Supplementary data
Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2022) 135 (19): jcs259856.
Published: 6 October 2022
... regulated. We identify the methyltransferase SETD2 as a negative regulator of global protein synthesis rates and cell size. SETD2 Histone methyltransferase Translation Cell size Nederlandse Organisatie voor Wetenschappelijk Onderzoek http://dx.doi.org/10.13039/501100003246 NWO-VICI...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2021) 134 (18): jcs258643.
Published: 27 September 2021
... of Col1a1 mRNA. Translation of collagen polypeptides occurs in the ER, where the polypeptide chains are translationally and post-translationally modified to form the triple helix ( Malhotra and Erlmann, 2015 ; Sharma et al., 2017 ; Zhang and Stefanovic, 2016 ). To examine the effects...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2021) 134 (1): jcs248476.
Published: 13 January 2021
... synthesis is an intricate process governed by upstream signalling pathways. Eukaryotic translation is a multistep process and can be separated into four distinct phases: initiation, elongation, termination and recycling of ribosomal subunits. Translation initiation, the focus of this article, is highly...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (22): jcs251983.
Published: 27 November 2020
... from consequences of defects in membrane proteins, quality control systems act to maintain protein homeostasis. The majority of these pathways act post-translationally; however, recent evidence reveals that membrane proteins are also subject to co-translational quality control during their synthesis...
Journal Articles
Journal Articles
Journal Articles
J Cell Sci (2019) 132 (12): jcs229252.
Published: 17 June 2019
... granules. Knockdown of OTUD4 in HeLa cells resulted in defects in stress granule formation and led to apoptotic cell death. Together, we characterize OTUD4 as a new RNA-binding protein with a suggested function in regulation of translation. * Present address: Centre for Discovery Brain Sciences...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (2): jcs224055.
Published: 18 January 2019
... directly through regulation of local protein synthesis ( Bramham and Wells, 2007 ; Sutton and Schuman, 2006 ). It is thought that synaptic mRNAs are transported in a translationally dormant state via interactions with RNA-binding proteins. Following synaptic stimulation, local mRNA translation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (19): jcs220244.
Published: 5 October 2018
... defined SGs are composed of translation initiation factors, 40S ribosomes, RNA-binding proteins and poly(A) + mRNAs. As such, they represent an important compartment for storage of mRNAs and regulation of their translation. Emerging work on SGs indicates that these structures might promote cellular...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (17): jcs220327.
Published: 3 September 2018
...Vilte Stonyte; Erik Boye; Beáta Grallert ABSTRACT It is generally accepted that global translation varies during the cell cycle and is low during mitosis. However, addressing this issue is challenging because it involves cell synchronization, which evokes stress responses that, in turn, affect...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
J Cell Sci (2018) 131 (9): jcs216176.
Published: 4 May 2018
.... It therefore appears that most of the non-localized mRNA molecules are translationally silent. In fact, transported mRNAs, such as β-actin mRNA in neurons, are known to exist in a masked and translationally inactive state ( Buxbaum et al., 2014 ). Recent work has shown that localized mRNAs are co-transported...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2016) 129 (24): 4534–4547.
Published: 15 December 2016
... with the cloverleaf structure of the EV71 RNA 5′UTR to inhibit viral RNA transcription, and binds to the internal ribosome entry site (IRES) of the EV71 5′UTR to attenuate viral RNA translation. Thus, EV71 stimulates SIRT1 production and activity, which in turn represses EV71 genome replication by inhibiting viral...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (12): 2407–2415.
Published: 15 June 2016
...Jirapas Jongjitwimol; Robert A. Baldock; Simon J. Morley; Felicity Z. Watts ABSTRACT Regulation of protein synthesis is crucial for cells to maintain viability and to prevent unscheduled proliferation that could lead to tumorigenesis. Exposure to stress results in stalling of translation, with many...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (3): 492–501.
Published: 1 February 2016
... of spermatocytes and spermatids ( Paronetto and Sette, 2010 ; Nguyen-Chi and Morello, 2011 ; Idler and Yan, 2012 ; Kleene, 2013 ). Many mRNA transcribed in spermatocytes and round spermatids are stored in a translationally inactive state for several days to more than two weeks, before their protein products can...
Includes: Supplementary data