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Keywords: Transformation
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Proteostasis
J Cell Sci (2014) 127 (3): 509–520.
Published: 1 February 2014
... epithelial cells require cullin-5–RING–E3-ubiquitin-ligase complexes (Cul5-CRLs) to prevent transformation by a Src–Cas signaling pathway. Removal of Cul5 stimulates growth-factor-independent growth and migration, membrane dynamics and colony dysmorphogenesis, which are all dependent on the endogenous...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (8): 1172–1182.
Published: 15 April 2008
... fibroblasts (HDFs), which are typically difficult to transform. We have previously shown that the bovine papillomavirus E5 protein, through its ability to crosslink and constitutively activate the PDGFβR, induces morphological transformation, enhanced growth and loss of contact inhibition (focus formation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (5): 819–827.
Published: 1 March 2006
... of mutated RAS were decreased in cells with reduced ERK activity as a result of APC overexpression, indicating that APC regulates RAS-induced ERK activation at least partly by reduction of the RAS protein level. APC regulates cellular proliferation and transformation induced by activation of both RAS and β...
Journal Articles
Journal Articles
J Cell Sci (2004) 117 (7): 989–998.
Published: 1 March 2004
... by influencing the RhoA-ROCK pathway that controls contractile actin filament assembly, the STAT family of transcription factors needed for transformation, and the Cbl ubiquitin ligase that controls Src protein levels. These studies also shed light on the role of focal adhesion kinase (FAK) downstream of v-Src...
Journal Articles
Journal Articles
J Cell Sci (2001) 114 (23): 4285–4292.
Published: 1 December 2001
...Fiamma Mantovani; Paola Massimi; Lawrence Banks The Dlg tumour suppressor protein is intimately involved in the control of cell contact and polarity. Previous studies have shown that hDlg is a target for a number of viral transforming proteins. In particular, the high risk human papillomavirus (HPV...
Journal Articles
J Cell Sci (2001) 114 (22): 4117–4126.
Published: 15 November 2001
... of completely blocking the transforming capacity of ErbB2 and ErbB3. These findings indicate that prostaglandins inhibit mammary epithelial proliferation and induce apoptosis, at least in part by antagonizing the actions of the neuregulins via receptor dephosphorylation. The strong blocking effect of PG-J 2...
Journal Articles
J Cell Sci (2001) 114 (16): 2921–2927.
Published: 15 August 2001
... and myotubularin homology domains, implying that growth inhibition may be an intrinsic property of wild-type Sbf1. Conversely, deletion of its conserved N-terminal 44 amino acids alone was sufficient to convert Sbf1 from an inhibitor of cellular growth to a transforming protein in NIH 3T3 cells. Oncogenic forms...
Journal Articles
J Cell Sci (2001) 114 (6): 1237–1246.
Published: 15 March 2001
... of anchorage-independent growth in soft agar and cell proliferation rate was not affected. Thus, cadherin loss does not induce transformation, despite inducing an invasive phenotype, a later stage of tumor progression. These experiments are especially relevant to tumor progression in cells with altered E...
Journal Articles
J Cell Sci (2000) 113 (9): 1543–1552.
Published: 1 May 2000
... 06 04 2000 19 02 2000 © 2000 by Company of Biologists 2000 CDK2 Cyclin Coiled body Nucleolus Transformation Cajal bodies (CBs; also known as ‘coiled’ bodies, see Gall et al., 1999 ) are nuclear organelles whose morphology and composition have been conserved from...
Journal Articles
Journal Articles
J Cell Sci (1995) 1995 (Supplement_19): 41–49.
Published: 1 January 1995
...Y. A. Lazebnik; A. Takahashi; G. G. Poirier; S. H. Kaufmann; W. C. Earnshaw ABSTRACT Apoptotic cell death is characterized by a dramatic morphological transformation during which apparently healthy cells suddenly initiate a comprehensive program of motility changes and degradative activities...
Journal Articles
J Cell Sci (1994) 107 (10): 2919–2929.
Published: 1 October 1994
... compared to those expressing p185 neuN . The effects of p185 neuN and p185 neuT expression on cell transformation depend on cell type. Expression of both p185 neuN and p185 neuT increases anchorage-independent growth of 31E cells, but only p185 neuT induces anchorage-independent growth of NIH 3T3...
Journal Articles
Journal Articles
J Cell Sci (1991) 99 (2): 453–463.
Published: 1 June 1991
...J. Russo; L. Tait; I. H. Russo ABSTRACT The present work describes the morphological pattern of c-Ha-ras-transformed MCF-10A cells. This immortalized human breast epithelial cell line was transfected utilizing the calcium phosphate technique with pHo6 containing the neomycin-resistant gene alone...
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Journal Articles
Journal Articles
J Cell Sci (1989) 94 (3): 517–525.
Published: 1 November 1989
... into primary mouse kidney cells or Rat-1 cells using the calcium phosphate technique and stable transformants were isolated after selection with G418. Transcription from the metallothionein promoter was inducible with heavy metals and produced an oncomodulin-specific mRNA. The presence of oncomodulin protein...
Journal Articles