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Keywords: Transcriptional repressor
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J Cell Sci (2024) 137 (3): jcs261931.
Published: 13 February 2024
... that anthracyclines fail to induce DNA damage in resistant cells, owing to the loss of expression of their target enzyme, TOP2B; this was caused by DNA-PKcs directly binding to its promoter upstream region as a transcriptional repressor. Importantly, DNA-PKcs kinase activity inhibition re-sensitized AML relapse...
Includes: Supplementary data
Journal Articles