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Keywords: Transcriptional repressor
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Journal Articles

DNA-PKcs-mediated transcriptional regulation of TOP2B drives chemoresistance in acute myeloid leukemia

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In collection:
Cell biology and disease , Nuclear structure and function
Saket V. Mishra, Archisman Banerjee, Debashmita Sarkar, Vishnuvarthan Thangarathnam, Bhausaheb Bagal, Syed K. Hasan, Shilpee Dutt
Journal: Journal of Cell Science
J Cell Sci (2024) 137 (3): jcs261931.
https://doi.org/10.1242/jcs.261931
Published: 13 February 2024
... that anthracyclines fail to induce DNA damage in resistant cells, owing to the loss of expression of their target enzyme, TOP2B; this was caused by DNA-PKcs directly binding to its promoter upstream region as a transcriptional repressor. Importantly, DNA-PKcs kinase activity inhibition re-sensitized AML relapse...
View articletitled, DNA-PKcs-mediated transcriptional regulation of TOP2B drives chemoresistance in acute myeloid leukemia
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Includes: Supplementary data
Journal Articles

A short Gfi-1B isoform controls erythroid differentiation by recruiting the LSD1–CoREST complex through the dimethylation of its SNAG domain

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Benoît Laurent, Voahangy Randrianarison-Huetz, Emilie Frisan, Charlotte Andrieu-Soler, Eric Soler, Michaela Fontenay, Isabelle Dusanter-Fourt, Dominique Duménil
Journal: Journal of Cell Science
J Cell Sci (2012) 125 (4): 993–1002.
https://doi.org/10.1242/jcs.095877
Published: 15 February 2012
...Benoît Laurent; Voahangy Randrianarison-Huetz; Emilie Frisan; Charlotte Andrieu-Soler; Eric Soler; Michaela Fontenay; Isabelle Dusanter-Fourt; Dominique Duménil Gfi-1B is a transcriptional repressor essential for the regulation of erythropoiesis and megakaryopoiesis. Here we identify Gfi-1B p32...
View articletitled, A short Gfi-1B isoform controls erythroid differentiation by recruiting the LSD1–CoREST complex through the dimethylation of its SNAG domain
Open the PDF for A short Gfi-1B isoform controls erythroid differentiation by recruiting the LSD1–CoREST complex through the dimethylation of its SNAG domain in another window
Includes: Supplementary data