...; generically referred to as CtBP1/2) as components of the PRDM14-mediated repressive complex. CtBP1/2 binding to PRDM14 depends on CBFA2T2, a core component of the PRDM14 complex. The loss of Ctbp1/2 impaired the PRDM14-mediated transcriptional repression required for pluripotency maintenance and transition...

... Transcriptional repression Maintaining oxygen homeostasis is essential for most organisms as hypoxia, even when transient, could trigger irreversible damage. Adaptation to reduced oxygen availability is indeed a major physiological challenge during embryonic development and in adulthood, but it is also...

... of these findings for our understanding of RTK signaling specificity in different biological processes. * Author for correspondence ([email protected]) © 2012. 2012 Capicua Cell proliferation CIC MAPK RTK signaling Transcriptional repression Tumor suppressor Receptor tyrosine kinase...

... in the nucleus. These results identify a stress-induced proteolytic pathway regulating cyclin C that requires nuclear to cytoplasmic relocalization and Not4p-mediated ubiquitylation. © 2012. 2012 Mediator complex Oxidative stress Transcriptional repression Ubiquitin protein degradation...

... locus, we have been able to demonstrate that BEND3 associates with the locus only when it is heterochromatic and dissociates upon activation of transcription. Furthermore, tethering BEND3 inhibits transcription from the locus, indicating that BEND3 is involved in transcriptional repression through its...

... to pericentric heterochromatin and KAKA foci, and suggest that KAKA foci may contain sumoylated KAP1 – the form of the protein that is active in transcriptional repression. ‡ Author for correspondence (e-mail: [email protected]) * These authors contributed equally to this work 19 11...

...Mehrnaz Fatemi; Paul A. Wade Methylation of DNA in mammalian cells serves to demarcate functionally specialized regions of the genome and is strongly associated with transcriptional repression. A highly conserved family of DNA-binding proteins characterized by a common sequence motif is widely...

... of an integral nuclear membrane protein and a histone modifier, at the nuclear periphery. HDAC3 LAP2β Histone modification Nuclear envelope Transcriptional repression Chromatin architecture The nuclear lamina of eukaryotic cells is a protein mesh that lines the nucleoplasmic side of the inner...

...-specific Kaiso-binding-site fusion with luciferase as reporter demonstrated that the identified NLS was crucial for Kaiso-mediated transcriptional repression. The identification of a Kaiso NLS thus clarifies the mechanism by which Kaiso translocates to the nucleus to regulate transcription of genes...

... ctn was to regulate Kaiso-mediated transcriptional repression. However, it remained unclear whether p120 ctn sequestered Kaiso in the cytosol or directly inhibited Kaiso transcriptional activity in the nucleus. Using minimal promoter assays, we show here that the regulatory effect of p120 ctn on Kaiso...

... adenovirus plus trichostatin A treatment (Fig. 6E). These results show that transcriptional repression of the Mlc3f transgene in the right ventricle is not modified by overexpression of transcription factors normally present at the time when regionalisation is established. Hand1 and Hand2 are bHLH...

... nuclear factor κB (NF-κB)- and E2F1- regulated targets. Thus, depletion of DAXX by RNAi has verified the crucial role of endogenous DAXX as an anti-apoptotic regulator, and has allowed the identification of probable physiological targets of DAXX transcriptional repression. In this report, we have used...

.... * Author for correspondence (e-mail: [email protected]) 16 11 2000 06 10 2000 © 2000 by Company of Biologists 2000 Nucleolus Chromatin Methylation Transcriptional repression rRNA Eukaryotic interphase nuclei are highly compartmentalised structures...

...Richard Meehan; Joe Lewis; Sally Cross; Xinsheng Nan; Peter Jeppesen; Adrian Bird ABSTRACT Methylated DNA in mammals is associated with transcriptional repression and nuclease resistant chromatin. In this review we discuss how these effects may be mediated by proteins that bind to methylated DNA...