... in fewer, enlarged lysosomes; TFEB-mediated lysosome biosynthesis does not contribute to swelling. Transcription factors Phosphoinositides Lysosomes Organelles Fusion Fission Natural Sciences and Engineering Research Council of Canada 10.13039/501100000038 Government...

...Jéröme Eeckhoute; Raphaël Métivier; Gilles Salbert Mammalian transcription factors (TFs) are often involved in differential cell-type- and context-specific transcriptional responses. Recent large-scale comparative studies of TF recruitment to the genome, and of chromatin structure and gene...

...Shihua He; James R. Davie The mammalian transcription factors Sp1 and Sp3 compete for the same DNA binding sites but play different roles in the regulation of expression of numerous genes. It is known that, in the interphase nucleus, Sp1 and Sp3 are organized into distinct foci. In this study, we...

... 4 5-trisphosphate receptors Nuclear envelope Transcription factors Gene expression Ionized calcium is a versatile second messenger that mediates a wide variety of biological processes in cells, such as secretion, contraction, differentiation, proliferation, programmed cell death and gene...

... Neovascularization Endothelial growth factors HGF/SF VEGF/VPF Transcription factors Trans-activation Signal transduction Promoter regions Vascular endothelial growth factor (VEGF/VPF) is recognized as a predominant regulator of blood vessel growth in cancer, wound repair and in numerous ischemic...

...-chloromethylketone. Both inhibitors are known to specifically inactivate proprotein convertases. The block was associated with impaired proteolytic activation of proIGF-1 receptor, absence of induction of the adipogenic transcriptional factor PPARγ and marked reduction of the nuclear translocation of the C/EBPβ...

... localization. The physiological implications of MEF2 carrying its own inhibitor to the nucleus are discussed. *Author for correspondence (e-mail: [email protected] ) 10 9 2001 © The Company of Biologists Limited 2001 2001 Transcription factors Cell compartmentation Muscle...

... and technical reasons, research effort has been focused overwhelmingly on receptor/ligand or transcription factor/DNA interactions. The task confronting biologists now is to link up these two extremes. Our present under-standing of these intermediary processes is in many cases rudimentary, but it is clear...

...Pierre-Olivier Angrand; Jean-Pierre Rousset; Mary C. Weiss ABSTRACT To evaluate the importance of the transcription factors known to bind to the albumin promoter as well as the parameters involved in their activity, we have used cotransfections with an albumin promoter- cat plasmid combined...

...Kevin A. W. Lee ABSTRACT Dimeric transcription factors that bind to DNA are often grouped into families on the basis of dimerization and DNA-binding specificities. cDNA cloning studies have established that members of the same family have structurally related dimerisation and DNA-binding domains...