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Keywords: Transcription factor
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Journal Articles
J Cell Sci (2022) 135 (20): jcs259900.
Published: 19 October 2022
... role in stem cell function. However, the mechanisms that modulate the function of ECM regulators in the stem cell niche are understudied. Here, we explored the role of the transcription factor (TF) ETS-1, which is expressed in the cathepsin-positive cell population, in regulating the expression...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (16): jcs260148.
Published: 19 August 2022
...-stimulated translocation of the GATA transcription factor GtaC as indicated by the distribution of a GFP–GtaC reporter. Erk2 was also found to be essential for the translocation of GtaC in response to external folate, a foraging signal that directs the chemotaxis of amoeba to bacteria. Erk1, the only other...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (9): jcs256792.
Published: 17 May 2021
...Radiya G. Ali; Helen M. Bellchambers; Nicholas Warr; Jehangir N. Ahmed; Kristen S. Barratt; Kieran Neill; Koula E. M. Diamand; Ruth M. Arkell ABSTRACT Zinc finger of the cerebellum (Zic) proteins act as classic transcription factors to promote transcription of the Foxd3 gene during neural crest...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (5): jcs217455.
Published: 25 February 2019
...Veer I. P. Keizer; Stefano Coppola; Adriaan B. Houtsmuller; Bart Geverts; Martin E. van Royen; Thomas Schmidt; Marcel J. M. Schaaf ABSTRACT Transcription factor mobility is a determining factor in the regulation of gene expression. Here, we have studied the intranuclear dynamics...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (21): 3740–3748.
Published: 1 November 2017
... regulation in neuroendocrine differentiated cells. This point mutation altered the promoter's regulatory mechanism by discrete changes in transcription factor TR occupancy and altered enrichment of the repressive chromatin modification of histone-3-lysine-9-trimethyl (H3K9Me3). Insights relating...
Journal Articles
J Cell Sci (2016) 129 (19): 3541–3552.
Published: 1 October 2016
... RNAs and their association with nuclear stress bodies (nSBs) of unknown function. Besides association with the Sat3 transcript, the nSBs are also known to recruit the transcription factors HSF1 and CREBBP, and several RNA-binding proteins, including the splicing factor SRSF1. We demonstrate here...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (13): 2573–2585.
Published: 1 July 2016
... activation are largely unknown. Recently, we identified a wave of immediate early transcription factors that are upregulated in human lymphatic endothelial cells (LECs) within the first 30 to 80 min after VEGFR-3 activation. Expression of these transcription factors must be regulated by additional pre...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (4): 717–728.
Published: 15 February 2016
... of the ATF6 gene by Runx2 and its repression by the Sox6 transcription factor. Runx2 and Sox6 act through their respective binding elements on the ATF6 gene. When overexpressed, ATF6 and ATF6a intensify chondrogenesis; our studies demonstrate that under the stimulation of ATF6 and ATF6a, chondrocytes tend...
Journal Articles
J Cell Sci (2015) 128 (23): 4353–4365.
Published: 1 December 2015
...Soshi Kanemoto; Yasuhiro Kobayashi; Teruhito Yamashita; Takeshi Miyamoto; Min Cui; Rie Asada; Xiang Cui; Kenta Hino; Masayuki Kaneko; Tomoko Takai; Koji Matsuhisa; Naoyuki Takahashi; Kazunori Imaizumi ABSTRACT Luman (also known as CREB3) is a type-II transmembrane transcription factor belonging...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (7): 1406–1416.
Published: 1 April 2014
... spectroscopy, to provide a quantitative model of the action of this transcription factor. This approach enabled us to distinguish two types of AR–DNA binding: very brief interactions, in the order of a few hundred milliseconds, and hormone-induced longer-lasting interactions, with a characteristic binding time...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (22): 5247–5258.
Published: 15 November 2013
...Hiroshi Senoo; Tsuyoshi Araki; Masashi Fukuzawa; Jeffrey G. Williams Summary MrfA, a transcription factor that regulates Dictyostelium prestalk cell differentiation, is an orthologue of the metazoan myelin gene regulatory factor (MRF) proteins. We show that the MRFs contain a predicted...
Journal Articles
J Cell Sci (2013) 126 (9): 2052–2059.
Published: 1 May 2013
... fluorescence in situ hybridization coupled to ‘high-precision’ localization, we show that promoters binding the same transcription factors and responding to the same signaling pathways tend to be co-transcribed in the same transcription factories. We go on to suggest how such spatial co-association might drive...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (21): 3780–3788.
Published: 1 November 2010
...Yoko Takigawa; Kenji Hata; Shuji Muramatsu; Katsuhiko Amano; Koichiro Ono; Makoto Wakabayashi; Akio Matsuda; Kenji Takada; Riko Nishimura; Toshiyuki Yoneda Sox9 is an essential transcription factor for chondrogenesis by regulating the expression of chondrogenic genes. However, its regulatory...
Journal Articles
J Cell Sci (2009) 122 (9): 1452–1460.
Published: 1 May 2009
...José-Manuel Mingot; Sonia Vega; Beatriz Maestro; Jesús M. Sanz; M. Angela Nieto Snail proteins are C 2 H 2 class zinc finger transcription factors involved in different processes during embryonic development, as well as in several adult pathologies including cancer and organ fibrosis...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (20): 3393–3402.
Published: 15 October 2008
...Virginie Firlej; Franck Ladam; Guillaume Brysbaert; Patrick Dumont; François Fuks; Yvan de Launoit; Arndt Benecke; Anne Chotteau-Lelievre Pea3 and Erm are transcription factors expressed in normal developing branching organs such as the mammary gland. Deregulation of their expression is generally...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (14): 2301–2307.
Published: 15 July 2007
..., transcription factor dynamics and the kinetics of RNA synthesis. These studies show how imaging gene expression in single living cells can reveal new regulatory mechanisms. They also expand our understanding of the role of chromatin and RNA dynamics in modulating cellular responses to developmental...
Journal Articles
J Cell Sci (2005) 118 (22): 5171–5180.
Published: 15 November 2005
...Robert P. Fisher In metazoans, cyclin-dependent kinase 7 (CDK7) has essential roles in both the cell-division cycle and transcription, as a CDK-activating kinase (CAK) and as a component of the general transcription factor TFIIH, respectively. Controversy over its double duty has been resolved...
Journal Articles
J Cell Sci (2003) 116 (9): 1707–1717.
Published: 1 May 2003
...Azadeh Arabi; Cecilia Rustum; Einar Hallberg; Anthony P. H. Wright c-Myc is a predominately nuclear transcription factor that is a substrate for rapid turnover by the proteasome system. Cancer-related mutations in c-Myc lead to defects in its degradation and thereby contribute to the increase...
Journal Articles
J Cell Sci (1992) 1992 (Supplement_16): 21–31.
Published: 1 January 1992
... enhancer to regulate differentially ε- versus β-globin gene transcription. Secondly, we show that the family of GATA transcription factors directs gene regulation in a variety of discrete cell types, and describe potential cellular target genes for each member of the GATA factor family, as well...