... in various cell types and how the structural plasticity of clathrin contributes to its functional diversity. Clathrin Electron microscopy Endocytosis Endosome Plasma membrane Trans-Golgi network Agence Nationale de la Recherche https://doi.org/10.13039/501100001665 ANR-20-CE13-0024-01...

... distinct transport vesicles at the trans -Golgi network (TGN), and the epsin-related proteins Ent3p and Ent5p (collectively Ent3p/5p) act as accessories for these adaptors. Recently, we showed that vesicle transport from the TGN is crucial for yeast Rab5 (Vps21p)-mediated endosome formation, and that Ent3p...

... that the ARF-GEF inhibitor Brefeldin A (BFA) induces the formation of BFA bodies, which are aggregates of Golgi stacks, trans -Golgi networks and recycling endosomes. Recycling endosomes are located in the centers of BFA bodies, while Golgi stacks surround them on their tran s sides. Live imaging of S2 cells...

...Syara Fujii; Kazuo Kurokawa; Ryota Inaba; Naoki Hiramatsu; Tatsuya Tago; Yuri Nakamura; Akihiko Nakano; Takunori Satoh; Akiko K. Satoh ABSTRACT Historically, the trans-Golgi network (TGN) has been recognized as a sorting center of newly synthesized proteins, whereas the recycling endosome (RE...

...Takuro Tojima; Yasuyuki Suda; Midori Ishii; Kazuo Kurokawa; Akihiko Nakano ABSTRACT The trans -Golgi network (TGN) acts as a sorting hub for membrane traffic. It receives newly synthesized and recycled proteins, and sorts and delivers them to specific targets such as the plasma membrane, endosomes...

... or paracrine manner. However, the status of the protein kinase D1 (PKD1; also known as PRKD1)-mediated classical protein secretory pathway, from the trans-Golgi network (TGN) to the cell surface, during cellular senescence and its role in the cellular senescence response remain unknown. Here, we show...

... system Endocytic pathway Rab protein Trans-Golgi network Sorting receptor Kreftforeningen 10.13039/100008730 4604944 5760850 Norges Forskningsråd 10.13039/501100005416 239903 230779 179573 The bidirectional transport between the trans-Golgi network (TGN...

... by a mechanism upstream of Sar1 and COPII, and also blocks exit from the trans-Golgi network. VSVG ER exit sites ER export COP II Secretory pathway Secretion Trans-Golgi network Deutsche Forschungsgemeinschaft 10.13039/501100001659 KA1751/4-1 Japan Society for the Promotion...

.../srep00069 Bock   J. B. , Klumperman   J. , Davanger   S. , Scheller   R. H. ( 1997 ). Syntaxin 6 functions in trans-Golgi network vesicle trafficking.   Mol. Biol. Cell   8 , 1261 – 1271 . 10.1091/mbc.8.7.1261 Bonifacino   J. S. , Hierro   A. ( 2011 ). Transport...

... 2014 ARF GTPase Flippase Golgin Trans-Golgi network ADP-ribosylation factors (ARFs) and ARF-like proteins (ARLs) are highly conserved small GTPases that function as major regulators of vesicular trafficking and cytoskeletal reorganization ( Donaldson and Jackson, 2011 ). The functions...

... an expanded trans-Golgi network, which could be rescued by PREPL expression. These data demonstrate PREPL as an AP-1 effector that takes part in the regulation of AP-1 membrane binding. PREPL is highly expressed in brain and at lower levels in muscle and kidney. Its deficiency causes hypotonia and growth...

...Kuan-Yu Chen; Pei-Chin Tsai; Ya-Wen Liu; Fang-Jen S. Lee Summary Golgins play diverse roles in regulating the structure and function of the Golgi. The yeast golgin Imh1p is targeted to the trans-Golgi network (TGN) through interaction of its GRIP domain with GTP-bound Arl1p. Recycling of Arl1p...

... evidence that post-Golgi membrane traffic plays a crucial role in autophagosome formation. Increased secretion of constitutive cargo from the trans-Golgi network (TGN) to the plasma membrane induced the formation of microtubule-associated protein light chain 3 (LC3)-positive structures. At the early phase...

... function remains unclear. The trans-Golgi network golgin GCC185 is required for maintenance of Golgi structure and distinct endosome-to-Golgi transport. We show here that GCC185 acts as a new effector for ARL4 to modulate Golgi organization. ARL4A directly interacts with GCC185 in a GTP-dependent manner...

...Jinbo Han; Yiguo Wang; Suming Wang; Chengwu Chi Furin is a proprotein convertase that cycles between the plasma membrane, endosomes and the trans-Golgi network (TGN), maintaining a predominant distribution in the latter. Mint3, a member of the Mint protein family, is involved in the signaling...

...Matthew N. J. Seaman The cation-independent mannose 6-phosphate receptor (CIMPR) cycles between the trans-Golgi network (TGN) and endosomes to mediate sorting of lysosomal hydrolases. The endosome-to-TGN retrieval of the CIMPR requires the retromer complex. Genetic, biochemical and structural data...

... soluble proteins traveling anterograde through the trans-Golgi network are not excluded from entering immature secretory granules, whether or not they have granule-targeting signals. However, the `sorting-for-entry' hypothesis suggests that soluble lumenal proteins lacking signals enter transport...

... recognition of those enzymes by mannose 6-phosphate receptors to ensure delivery to lysosomes. Uncovering enzyme has been identified on the trans-Golgi network at steady state. It has been shown to traffic to the plasma membrane from where it is rapidly internalized via endosomal structures, the process being...

...Merran C. Derby; Catherine van Vliet; Darren Brown; Michael R. Luke; Lei Lu; Wanjin Hong; Jennifer L. Stow; Paul A. Gleeson The four mammalian golgins, p230/golgin-245, golgin-97, GCC88 and GCC185 are targeted to trans -Golgi network (TGN) membranes by their C-terminal GRIP domain in a G-protein...

... at the trans-Golgi network, which suggests that E/ANTH domains are universal components of the machinery for clathrin-mediated membrane budding. ‡ Author for correspondence (e-mail: [email protected] ) * These authors contributed equally to this Commentary © The Company of Biologists...