.... , Hatanaka , M. , Nagao , K. , Nakaseko , Y. , Kanoh , J. , Kokubu , A. , Ebe , M. and Yanagida , M. ( 2007 ). Rapamycin sensitivity of the Schizosaccharomyces pombe tor2 mutant and organization of two highly phosphorylated TOR complexes by specific and common subunits . Genes...

... Schizosaccharomyces pombe . Nat. Biotechnol.   28 , 617 - 623 . 10.1038/nbt.1628 Lee , J. , Moir , R. D. and Willis , I. M. ( 2009 ). Regulation of RNA polymerase III transcription involves SCH9-dependent and SCH9-independent branches of the target of rapamycin (TOR) pathway . J. Biol. Cehm...

...Karen Baker; Sara Kirkham; Lenka Halova; Jane Atkin; Mirita Franz-Wachtel; David Cobley; Karsten Krug; Boris Maček; Daniel P. Mulvihill; Janni Petersen ABSTRACT The timing of cell division is controlled by the coupled regulation of growth and division. The target of rapamycin (TOR) signalling...

... was phosphorylated when mitophagy was induced. We found that Pp Atg32 expression was suppressed by Tor and the downstream Pp Sin3– Pp Rpd3 complex. Inhibition of Tor by rapamycin induced Pp Atg32 expression, but could neither phosphorylate Pp Atg32 nor induce mitophagy. Based on these findings, we conclude...

...Jane Atkin; Lenka Halova; Jennifer Ferguson; James R. Hitchin; Agata Lichawska-Cieslar; Allan M. Jordan; Jonathon Pines; Claudia Wellbrock; Janni Petersen ABSTRACT The target of rapamycin (TOR) kinase regulates cell growth and division. Rapamycin only inhibits a subset of TOR activities. Here we...

..., induces Gcn2-dependent phosphorylation of eIF2α. * Author for correspondence ( [email protected] ) 11 10 2012 © 2012. Published by The Company of Biologists Ltd 2012 S. pombe TOR Rapamycin Gcn2 eIF2α In response to diverse environmental stresses, the phosphorylation...

... Cell growth TOR Gtr1 Gtr2 Vam6 Cell survival depends on continuous sensing of the nutritional environment and adjusting cell growth, cell division and cell differentiation accordingly. In the presence of nutrients, Schizosaccharomyces pombe cells grow and divide, but when nutrients...

...T. Harshani Peiris; Frank Weckerle; Elyse Ozamoto; Daniel Ramirez; Devon Davidian; Marcos E. García-Ojeda; Néstor J. Oviedo Target of Rapamycin (TOR) controls an evolutionarily conserved signaling pathway that modulates cellular growth and division by sensing levels of nutrients, energy and stress...

... phenotypes. This suppression does not affect Egfr directly, but rather overcomes the translational block of grk messages seen in spindle mutants. Lnk was recently identified as a component of the insulin/insulin-like growth factor signaling (IIS) and TOR pathway. Interestingly, direct inhibition of TOR...

...Sonya Hartmuth; Janni Petersen TOR signalling coordinates growth and division to control cell size. Inhibition of Schizosaccharomyces pombe Tor1, in response to a reduction in the quality of the nitrogen source (nutrient stress), promotes mitotic onset through activation of the mitogen-activated...

... and undergo cell differentiation. The molecular mechanisms underlying this response are not fully understood. Here, we demonstrate that Tor2, a fission yeast member of the TOR protein kinase family, is central to controlling the switch between cell growth and cell differentiation in response to nutrient...

...Parthive H. Patel; Fuyuhiko Tamanoi The accumulation of free radical damage to an organism over its lifespan can cause premature aging and disease including cancer, atherosclerosis and neurodegenerative disorders. The well-conserved Rheb–Target-of-rapamycin (TOR)–S6-kinase (S6K) signaling pathway...

... find that flies with reduced dRheb activity are hypersensitive to rapamycin, an inhibitor of the growth regulator TOR. In cultured cells, the effect of overexpressing dRheb was blocked by the addition of rapamycin. These results imply that dRheb is involved in TOR signaling. © The Company...