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Keywords: Tks5
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J Cell Sci (2022) 135 (12): jcs259576.
Published: 28 June 2022
... 2022 Summary: Syntaxin 7 contributes to invadopodia formation and associated activity by forming multiple SNARE complexes that support the delivery of essential cargo to invadopodial sites. STX7 VAMP2 VAMP3 STX4 MT1-MMP Tks5 Cortactin Invadopodia SNAREs Ministry of Human...
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J Cell Sci (2016) 129 (23): 4341–4353.
Published: 1 December 2016
... in mediating invadopodia function during breast cancer cell invasion. We also identify Tks5 (also known as SH3PXD2A), a known Src kinase substrate, as a new Rab40b effector protein and show that Tks5 functions as a tether that mediates Rab40b-dependent targeting of transport vesicles containing MMP2 and MMP9...
Includes: Supplementary data
Journal Articles
In collection:
Migration
J Cell Sci (2016) 129 (14): 2804–2816.
Published: 15 July 2016
... tumors, and progressively reduced in more aggressive stages of non-small-cell lung cancers. We show that SNX9 is localized at invadopodia where it directly binds the invadopodia marker TKS5 and negatively regulates invadopodia formation and function. SNX9 depletion increases invadopodia number...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (15): 2727–2740.
Published: 1 August 2009
... adaptor protein Tks5 (also known as SH3PXD2A) cooperates with Src tyrosine kinase to promote invadopodia formation but the underlying pathway is not clear. Here we show that Src phosphorylates Tks5 at Y557, inducing it to associate directly with the SH3-SH2 domain adaptor proteins Nck1 and Nck2...
Includes: Supplementary data