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Keywords: Titin
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Journal Articles
J Cell Sci (2021) 134 (18): jcs258684.
Published: 17 September 2021
...Ariane Biquand; Simone Spinozzi; Paola Tonino; Jérémie Cosette; Joshua Strom; Zaher Elbeck; Ralph Knöll; Henk Granzier; William Lostal; Isabelle Richard ABSTRACT Titin is a giant sarcomeric protein that is involved in a large number of functions, with a primary role in skeletal and cardiac...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (4): 858–870.
Published: 15 February 2014
...Zsolt Mártonfalvi; Pasquale Bianco; Marco Linari; Marco Caremani; Attila Nagy; Vincenzo Lombardi; Miklós Kellermayer ABSTRACT Titin is a giant elastomeric muscle protein that has been suggested to function as a sensor of sarcomeric stress and strain, but the mechanisms by which it does so...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (11): 1841–1851.
Published: 01 June 2008
... with the Z-disk is mediated by Z-disk titin. Here, we unravel the molecular basis for the unusual localization of obscurin, a Z-disk-associated protein, to the M-band, where its invertebrate analogue UNC-89 is also localized. The first three domains of the N-terminus of obscurin bind to the most C-terminal...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (13): 2190–2204.
Published: 01 July 2007
...Lacramioara Fabian; Xuequin Xia; Deepa V. Venkitaramani; Kristen M. Johansen; Jørgen Johansen; Deborah J. Andrew; Arthur Forer Titin, the giant elastic protein found in muscles, is present in spindles of crane-fly and locust spermatocytes as determined by immunofluorescence staining using three...
Journal Articles
J Cell Sci (2006) 119 (20): 4322–4331.
Published: 15 October 2006
...Hanny Musa; Stephen Meek; Mathias Gautel; Dianna Peddie; Andrew J. H. Smith; Michelle Peckham Titin, a multifunctional protein that stretches from the Z-disk to the M-band in heart and skeletal muscle, contains a kinase domain, phosphorylation sites and multiple binding sites for structural...
Journal Articles
J Cell Sci (2006) 119 (2): 239–249.
Published: 15 January 2006
... out a two-hybrid screen with a human skeletal-muscle cDNA library, using the Ig-fold domain of lamin A as bait. The C-terminal region of titin was recovered twice. Previous investigators showed that nuclear isoforms of titin are essential for chromosome condensation during mitosis. Our titin fragment...
Journal Articles
J Cell Sci (2004) 117 (24): 5781–5789.
Published: 15 November 2004
...Attila Nagy; Paola Cacciafesta; László Grama; András Kengyel; András Málnási-Csizmadia; Miklós S. Z. Kellermayer Parts of the PEVK (Pro-Glu-Val-Lys) domain of the skeletal muscle isoform of the giant intrasarcomeric protein titin have been shown to bind F-actin. However, the mechanisms...
Journal Articles
J Cell Sci (2004) 117 (15): 3175–3188.
Published: 01 July 2004
... the giant protein, titin), microtubules and/or nuclear factors. We investigated the role of MURF-2, the least-characterized family member, in primary cultures of embryonic chick skeletal and cardiac myocytes. MURF-2 is detected as two species (∼55 kDa and ∼60 kDa) in embryonic muscle, which are down...
Journal Articles
J Cell Sci (2003) 116 (23): 4811–4819.
Published: 01 December 2003
...Gaynor Miller; Hanny Musa; Matthias Gautel; Michelle Peckham Titin is the largest protein known, and is essential for organising muscle sarcomeres. It has many domains with a variety of functions, and stretches from the Z-line to the M-line in the muscle sarcomere. Close to the M-line, titin...
Journal Articles
J Cell Sci (2002) 115 (23): 4469–4482.
Published: 01 December 2002
... and are transiently present in the myofibril. We show here that the novel tubulin-associated RING/B-box protein MURF2 associates transiently with microtubules, myosin and titin during sarcomere assembly. During sarcomere assembly, MURF2 first associates with microtubules at the exclusion of tyrosinated tubulin...