... and proliferation studies, were performed to determine the role of E-cadherin and its ligand α E β 7 integrin during human thymocyte development. Normal thymuses were obtained from children (<8 years) undergoing cardiac surgery after informed consent of their parents. Thymocytes were isolated from...

... 1 integrin heterodimers might initiate this intracellular pathway. Thymic epithelial primary cultures were derived from normal thymuses of children (<5 years of age) undergoing cardiac surgery ( Green et al., 1979 ). Briefly, thymus specimens were minced and treated with a 0.05% trypsin...

... influenced by this event, if only for a brief period of time. We thank the Sir Jules Thorn Charitable Trust for financial support to work on the thymus gland, and Mr Ian W. Morris for technical assistance. REFERENCES Andrews , S. B. , Kirk , R. G. & Mazurkiewicz , J. E...