...A. Wayne Orr; Carrie A. Elzie; Dennis F. Kucik; Joanne E. Murphy-Ullrich The matricellular extracellular matrix protein thrombospondin-1 (TSP1)stimulates focal adhesion disassembly through a sequence (known as the hep I peptide) in its heparin-binding domain. This mediates signaling through...

...Joanne S. Lymn; Mahendra K. Patel; Gerard F. Clunn; Sarafina J. Rao; Karen L. Gallagher; Alun D. Hughes Thrombospondin-1 is a large matricellular protein that acts as a pleiotropic growth factor for human vascular smooth muscle cells, and may play a role in the progression of vascular disease...

...Josephine C. Adams ABSTRACT The organisation of the actin cytoskeleton was examined in H9c2 and human intestinal smooth muscle cells adherent on fibronectin or thrombospondin-1. Whereas cells adherent on fibronectin adopted a polygonal shape and rapidly assembled prominent stress fibres and focal...

... and increased levels of thrombospondin-1 by comparison to the permissive matrices. In contrast, no differences were detected in the relative levels of laminin. The roles of tenascin and thrombospondin-1 in endothelial sprouting were confirmed using specific antibodies. Immunolocalisation studies revealed...