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Keywords: Thrombin
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Journal Articles
J Cell Sci (2022) 135 (7): jcs258809.
Published: 1 April 2022
... is typically reliant on bleb formation. Here we demonstrate that thrombin induces dynamic blebbing in the MDA-MB-231 breast cancer cell line and confirm that protease-activated receptor 1 (PAR1) activation is sufficient to induce this effect. Cell confinement has been implicated as a driving force in bleb...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (17): jcs258823.
Published: 8 September 2021
.... Biosensor Rho GTPase Endothelial cell Thrombin Rho Nederlandse Organisatie voor Wetenschappelijk Onderzoek http://dx.doi.org/10.13039/501100003246 ALWOP.306 Universiteit van Amsterdam http://dx.doi.org/10.13039/501100001827 Rho GTPases function as a molecular switch...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (8): jcs254888.
Published: 22 April 2021
... by dysregulated thrombin receptor trafficking promotes breast carcinoma cell invasion . Mol. Cell. Biol. 24 , 1990 - 1999 . 10.1128/MCB.24.5.1990-1999.2004 Chan , S. W. , Lim , C. J. , Guo , K. , Ng , C. P. , Lee , I. , Hunziker , W. , Zeng , Q. and Hong , W. ( 2008...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2007) 120 (6): 921–928.
Published: 15 March 2007
... Thrombin Trafficking Coagulant protease Protease-activated receptors (PARs) are G-protein-coupled receptors (GPCRs) that signal in response to extracellular proteases. There are four PARs encoded in the mammalian genome. PAR1, the prototype for this family, transmits cellular responses...
Journal Articles
J Cell Sci (2003) 116 (12): 2399–2408.
Published: 15 June 2003
... thrombin is a potent cell modulator obligately produced at the site of clot formation, we hypothesized that the amount of cell-surface A2 and p11 might be altered by thrombin with consequent effects on plasmin generation. In support of this hypothesis, immunofluorescence microscopy and hydrophilic...
Journal Articles
Journal Articles
J Cell Sci (2000) 113 (24): 4427–4433.
Published: 15 December 2000
... the receptor. Activators of PAR-2 include trypsin and mast cell tryptase. Skeletal myoblasts are known to express PAR-1, a thrombin receptor. The current study was undertaken to determine whether myoblasts express PAR-2. Primary neonatal rat and mouse skeletal myoblast cultures were shown to express PAR-2...
Journal Articles
J Cell Sci (1995) 108 (9): 3059–3066.
Published: 1 September 1995
...Alison L. Jenkins; Gareth L. Howells; Emma Scott; Bernard F. Le Bonniec; Michael A. Curtis; Stuart R. Stone ABSTRACT Human α-thrombin was a chemoattractant for human neutrophils yielding a maximal response of similar magnitude to that observed with formyl-Met-Leu-Phe. The observed chemotaxis...
Journal Articles
J Cell Sci (1993) 104 (2): 409–413.
Published: 1 February 1993
... chromatography and their mitogenic activity was assessed before and after treatment with thrombin. The Aα 1 , Aβ 2 and Bβchains where all found to stimulate fibroblast replication (23 2.9%, 29.2 5.3% and 31.4 5% stimulation above control, respectively) and on the addition of thrombin this activity was enhanced...
Journal Articles
J Cell Sci (1990) 96 (4): 737–744.
Published: 1 August 1990
...René Moser; Peter Groscurth; Jorg Fehr ABSTRACT Thrombin has been reported to elicit two temporally different effects on neutrophil-endothelial interaction, categorically described as ‘neutrophil adhesion’: one expressed within a few minutes, the other after several hours of endothelial...
Journal Articles
J Cell Sci (1990) 96 (2): 271–274.
Published: 1 June 1990
...Andrew J. Gray; Jack T. Reeves; Nicholas K. Harrison; Peter Winlove; Geoffrey J. Laurent ABSTRACT Fibroblasts adhere to, and readily grow into, fibrin clots that form as a result of the cleavage of fibrinogen by thrombin. Subsequent fibroblast replication is believed to be stimulated by mitogens...