... recently described physiological roles of prion protein and the advanced understanding of pathogenesis of prion disease they have afforded. Importantly, prion protein may also be involved in the pathogenesis of other neurodegenerative disorders such as Alzheimer's and Parkinson's disease. Therapeutic...

... the suitability of TFEB as a therapeutic target of clinical relevance. * These authors contributed equally to this work ‡ Author for correspondence ( [email protected] ) Competing interests The authors declare no competing or financial interests. © 2021. Published by The Company...

... and propagate from cell to cell through macropinocytosis. Progress is being made towards using macropinocytosis therapeutically, either to deliver drugs to or cause cell death by inducing catastrophically rapid fluid uptake. Mechanistically, the Ras signalling pathway plays a prominent and conserved activating...