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Keywords: Testis
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Journal Articles
Journal Articles
J Cell Sci (2018) 131 (19): jcs221481.
Published: 8 October 2018
... MARVEL transmembrane domain containing) protein family remain to be determined. In this study, we focused on the testis-specific mouse CMTM gene cluster ( Cmtm1 , Cmtm2a and Cmtm2b ) and generated CRISPR/Cas9-mediated mutant mice to examine their physiological functions. Although Cmtm1 mutant mice were...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (22): 4870–4882.
Published: 15 November 2014
...Ka-Wai Mok; Dolores D. Mruk; C. Yan Cheng ABSTRACT Mammalian target of rapamycin complex 1 (mTORC1) is an emerging regulator of blood–tissue barriers that utilizes ribosomal protein S6 (rpS6) as the downstream signaling molecule. To explore the role of rpS6 in blood–testis barrier (BTB) function...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (23): 5677–5689.
Published: 1 December 2012
...Xiang Xiao; C. Yan Cheng; Dolores D. Mruk Summary The mechanism underlying the movement of preleptotene/leptotene spermatocytes across the blood–testis barrier (BTB) during spermatogenesis is not well understood largely owing to the fact that the BTB, unlike most other blood–tissue barriers...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (1): 40–50.
Published: 1 January 2010
... of a testis-enriched exon from the Acinus gene, whereas 9G8 and Tra2-β repressed this exon. We propose that hRBMY associates with regions of the nucleus enriched in nascent RNA and participates in the regulation of specific splicing events in the germline by modulating the activity of constitutively expressed...
Includes: Supplementary data
Journal Articles
J Cell Sci (2004) 117 (24): 5835–5845.
Published: 15 November 2004
...Nanaho Fukuda; Kentaro Yomogida; Masaru Okabe; Kazushige Touhara Although a subset of the olfactory receptor (OR) gene family is expressed in testis, neither their developmental profile nor their physiological functions have been fully characterized. Here, we show that MOR23 (a mouse OR expressed...
Journal Articles
Journal Articles
Journal Articles
Journal Articles
J Cell Sci (2002) 115 (17): 3491–3496.
Published: 1 September 2002
...Peter J. O'Shaughnessy; Heather Johnston; Louise Willerton; Paul J. Baker During testicular development, fetal and adult populations of Leydig cells arise sequentially. Previous studies have shown that androgen action is required for normal steroidogenic activity in the mouse testis. Therefore...
Journal Articles
J Cell Sci (2001) 114 (17): 3177–3188.
Published: 1 September 2001
... of the cadherin/catenin complex to the actin cytoskeleton via α-catenin. To date, it is not clear how different cell types achieve the variable strength of cell-cell adhesion clearly needed in a multicellular organism. Here, we report the cloning and molecular characterization of αT(testis)-catenin, a novel human...
Journal Articles
J Cell Sci (2001) 114 (11): 2125–2134.
Published: 1 June 2001
...Juliette Longin; Patricia Guillaumot; Marie-Agnès Chauvin; Anne-Marie Morera; Brigitte Le Magueresse-Battistoni Metalloproteases (MMPs) are likely to be involved in the restructuring events occurring in the testis throughout development. We here demonstrate that membrane-type 1 (MT1)-MMP...
Journal Articles
Journal Articles
J Cell Sci (2000) 113 (1): 161–168.
Published: 15 June 2000
...Wei Yan; Janne Suominen; Jorma Toppari ABSTRACT Stem cell factor (SCF) plays an important role in migration, adhesion, proliferation, and survival of primordial germ cells and spermatogonia during testicular development. However, the function of SCF in the adult testis is poorly described. We have...
Journal Articles
J Cell Sci (2000) 113 (4): 673–682.
Published: 15 February 2000
... report here evidence for an involvement of mammalian SMC1 and SMC3 proteins in meiosis. Immunofluorescence analysis of testis sections showed intense chromatin association in meiotic prophase cells, weaker staining in round spermatids and absence of the SMC proteins in elongated spermatids...
Journal Articles
J Cell Sci (1999) 112 (20): 3455–3462.
Published: 15 October 1999
...Charles Pineau; Suzan McCool; Marc J. Glucksman; Bernard Jégou; Adrian R. Pierotti ABSTRACT Thimet oligopeptidase (TOP:E.C. 3.4.24.15) is a thiol sensitive metalloendopeptidase which is widely distributed and active in most tissues including testis, brain and pituitary. In the median eminence...
Journal Articles
Journal Articles
J Cell Sci (1996) 109 (11): 2737–2745.
Published: 1 November 1996
.... Although present in brain and several other tissues, NRD convertase is particularly abundant in testis, where its expression appeared to be restricted to germ cells. Low levels of both mRNA and its corresponding protein were detected early in spermatogenesis. However, a marked accumulation of the protein...
Journal Articles
J Cell Sci (1993) 105 (1): 1–5.
Published: 1 May 1993
... 848 amino acids and has great sim-ilarity with brain dynamin and the shibire product. Northern blot analysis and in situ hybridization revealed its expression to be specific to the seminiferous tubules in the testis. Dynamin-2 (testis type dynamin) was expressed in germ-cell-depleted testis as well...
Journal Articles
J Cell Sci (1989) 94 (1): 61–71.
Published: 1 September 1989
...B. K. A. Rasheed; E. C. Whisenant; R. D. Ghai; V. E. Papaioannou; Y. M. Bhatnagar ABSTRACT An Hl histone variant, H1a, has been isolated and purified from the mouse testis. Biochemical and amino acid analyses indicate its similarity with the rat testis H1a. Specific antibodies against the purified...