1-20 of 30
Keywords: Telomere
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles
J Cell Sci (2020) 133 (22): jcs253724.
Published: 30 November 2020
... thermophila , the meiotic prophase nucleus stretches enormously, and chromosomes assume a bouquet-like arrangement in which telomeres and centromeres are attached to opposite poles of the nucleus. We have identified and characterized three meiosis-specific genes [meiotic nuclear elongation 1-3 ( MELG1-3...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (22): jcs253724.
Published: 30 November 2020
... thermophila , the meiotic prophase nucleus stretches enormously, and chromosomes assume a bouquet-like arrangement in which telomeres and centromeres are attached to opposite poles of the nucleus. We have identified and characterized three meiosis-specific genes [meiotic nuclear elongation 1-3 ( MELG1-3...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2015) 128 (12): 2314–2327.
Published: 15 June 2015
.... The Atm 3′UTR contains many potential microRNA target sites, and, notably, target sites for several miRNAs depleted in both conditional knockout mice were highly effective at promoting repression. RNF8, a telomere-associated protein whose localization is controlled by the MDC1–ATM kinase cascade, normally...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (10): 1969–1981.
Published: 15 May 2015
...Raphaëlle Dubruille; Benjamin Loppin ABSTRACT In Drosophila , telomere-capping proteins have the remarkable capacity to recognize chromosome ends in a sequence-independent manner. This epigenetic protection is essential to prevent catastrophic ligations of chromosome extremities. Interestingly...
Journal Articles
Journal Articles
Journal Articles
J Cell Sci (2014) 127 (4): 752–762.
Published: 15 February 2014
...Sicong Zeng; Lvjun Liu; Yi Sun; Pingyuan Xie; Liang Hu; Ding Yuan; Dehua Chen; Qi Ouyang; Ge Lin; Guangxiu Lu ABSTRACT High telomerase activity is a characteristic of human embryonic stem cells (hESCs), however, the regulation and maintenance of correct telomere length in hESCs is unclear...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2013) 126 (2): 676–687.
Published: 15 January 2013
... sequences at the ends of telomeres. Telomerase can repetitively reverse transcribe its short RNA template, acting processively to add multiple telomeric repeats onto the same DNA substrate. The contribution of enzyme processivity to telomere length regulation in human cells is not well characterized...
Journal Articles
J Cell Sci (2011) 124 (12): 2041–2048.
Published: 15 June 2011
...Giosalba Burgio; Francesca Cipressa; Antonia Maria Rita Ingrassia; Giovanni Cenci; Davide F. V. Corona Telomeres are specialized structures at the end of eukaryotic chromosomes that are required to preserve genome integrity, chromosome stability and nuclear architecture. Telomere maintenance...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2008) 121 (21): 3553–3560.
Published: 1 November 2008
... of a trimethylguanosine (m 3 G) cap structure at the 5′ end of the RNA. Here, we report that the yeast snRNA and snoRNA methyltransferase Tgs1 is responsible for TLC1 m 3 G cap formation. The absence of Tgs1 caused changes in telomere length and structure, improved telomeric silencing and stabilized telomeric...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (20): 3678–3687.
Published: 15 October 2007
...Pascale Rossignol; Sarah Collier; Max Bush; Peter Shaw; John H. Doonan Chromosome integrity is maintained via the actions of ribonucleoprotein complexes that can add telomeric repeats or can protect the chromosome end from being degraded. POT1 (protection of telomeres 1), a class of single-stranded...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (5): 713–721.
Published: 1 March 2007
... and aging at cellular and molecular levels. The protein mutated in WS, WRN, appears to play a major role in genome stability, particularly during DNA replication and telomere metabolism. Much of the pathophysiology associated with WS, including the rapid onset of cellular senescence, early cancer onset...
Journal Articles
Journal Articles
J Cell Sci (2004) 117 (24): 5937–5947.
Published: 15 November 2004
... nuclear foci that shift over the course of the cell cycle and associate with the mitotic spindle, a pattern of localization reminiscent of that described previously for both mini-chromosomes and telomeres. By combining fluorescence in situ hybridization with indirect immunofluorescence, we confirmed...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2004) 117 (17): 3935–3945.
Published: 1 August 2004
...Suisheng Zhang; Peter Hemmerich; Frank Grosse The telomeric repeat binding factor 2 (TRF2) specifically recognizes TTAGGG tandem repeats at chromosomal ends. Unexpectedly immunofluorescence studies revealed a prominent nucleolar localization of TRF2 in human cells, which appeared as discrete dots...
Journal Articles