.... Zammit; Henning Wackerhage ABSTRACT VGLL proteins are transcriptional co-factors that bind TEAD family transcription factors to regulate events ranging from wing development in fly, to muscle fibre composition and immune function in mice. Here, we characterise Vgll3 in skeletal muscle. We found...

... of the Tead family, control cell proliferation and apoptosis. Here, we established an in vitro model system that shows cell competition in mouse NIH3T3 embryo fibroblast cells. Co-culture of Tead-activity-manipulated cells with normal (wild-type) cells caused cell competition. Cells with reduced Tead activity...

...Maren Diepenbruck; Lorenz Waldmeier; Robert Ivanek; Philipp Berninger; Phil Arnold; Erik van Nimwegen; Gerhard Christofori ABSTRACT The cellular changes during an epithelial–mesenchymal transition (EMT) largely rely on global changes in gene expression orchestrated by transcription factors. Tead...