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Keywords: Taxol
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Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2024) 137 (2): jcs261522.
Published: 31 January 2024
... to the depolymerising drug nocodazole or the microtubule-stabilising drug taxol, which is quantitated by mass spectrometry. Our approach is benchmarked by co-segregation of tubulin and previously established microtubule-binding proteins. We then identify several novel candidate microtubule-binding proteins, from which...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (15): 2579–2585.
Published: 1 August 2009
... chemotherapy forms the mainstay of cancer treatment, and agents that disrupt mitotic spindle assembly – so called `anti-mitotics' – are commonly used to treat a wide variety of cancers. Traditional anti-mitotic agents include the microtubule toxins such as taxol, other taxanes and the vinca alkaloids, all...
Journal Articles
J Cell Sci (2009) 122 (14): 2337–2350.
Published: 15 July 2009
... ; [email protected]) © The Company of Biologists Limited 2009 2009 Calcium Gene transcription Ins P 3 Nucleus Paclitaxel Ryanodine Signalling Spindle checkpoint Taxol Calcium (Ca 2+) is a key player in signal transduction. It modulates diverse cellular activities ranging from...
Journal Articles
J Cell Sci (2001) 114 (21): 3885–3897.
Published: 1 November 2001
... to substantially reduce the level of ATP in living cells and we used Taxol to halt microtubule dynamics. Both treatments slowed the dynamics of 5×GFP-EMTB speckles observed by FSM. We also used fluorescence recovery after photobleaching (FRAP) to quantify the half-time of binding and dissociation of the 5×GFP-EMTB...
Journal Articles
J Cell Sci (2001) 114 (2): 281–291.
Published: 15 January 2001
... conditions. However, stabilization of microtubules by taxol did not affect the proliferation of mitochondria during the cell cycle, yet a prolonged incubation of cells with taxol induced an abnormal accumulation of mitochondria in cells arrested in G 2 /M phase of cell cycle. Taxol-induced accumulation...
Journal Articles
Journal Articles
J Cell Sci (1999) 112 (8): 1273–1282.
Published: 15 April 1999
...-specific drugs, colcemid and taxol, indicate that the organization of this cortex is under microtubular control. * Author for correspondence at present address: Cancer Research Center, Kashirscoye, Shosse 24, Moscow 115478, Russia (e-mail: [email protected]) 23 03 1999 08 02 1999...
Journal Articles
J Cell Sci (1999) 112 (4): 455–466.
Published: 15 February 1999
... redistribution of the protein during mitosis, B23 also becomes associated with mitotic spindle poles starting from early prometaphase onwards. Colocalization of B23 with the protein NuMA (Nuclear Mitotic Apparatus protein) was studied in mitotic cells and taxol-arrested cells. During the onset of mitosis, we...
Journal Articles
Journal Articles
J Cell Sci (1997) 110 (24): 3091–3098.
Published: 15 December 1997
..., nocodazole and taxol. Fluctuations in the rate of retraction of the margin were about twice as powerful as fluctuations in the rate of protrusion. High-frequency fluctuations were also apparent in the cell track and in measures of cell spreading, shape and speed. These rapid fluctuations were also all...
Journal Articles
Journal Articles
J Cell Sci (1996) 109 (2): 509–516.
Published: 1 February 1996
... is analyzed under a given velocity distribution along its length. Microtubules incubated with taxol after polymerization are measured to be more flexible than those without taxol added. On the other hand, MAPs are shown to increase microtubule stiffness. * Author for correspondence (e-mail: felgner...
Journal Articles
J Cell Sci (1996) 109 (1): 21–32.
Published: 1 January 1996
... relation to the actin-based cytoskeleton and to ligand-containing endosomes during receptor-mediated endocytosis and the alterations in its structure and disposition by the microtubule pertubant, Taxol. By co-localization studies, we have been able to demonstrate that the microtubules have a significant...
Journal Articles
Journal Articles
J Cell Sci (1995) 108 (4): 1659–1667.
Published: 1 April 1995
...V. B. Dugina; A. Y. Alexandrova; K. Lane; E. Bulanova; J. M. Vasiliev ABSTRACT The effects of the microtubular drugs colcemid and taxol on the morphological changes induced by hepatocyte growth factor/scatter factor (HGF/SF) in MDCK cells were studied. Dynamic changes in the area and shape...
Journal Articles
J Cell Sci (1994) 107 (10): 2839–2849.
Published: 1 October 1994
... of this MAP; namely, its unusually tight association with a calcium-insensitive population of MTs in the presence of taxol, was exploited in devising an efficient purification strategy. Because of the MAP’s tenacious association with a stable population of MTs, and because it appeared to contribute...
Journal Articles
J Cell Sci (1992) 102 (3): 557–567.
Published: 1 July 1992
...Patricia J. Harris; Elise L. Clason ABSTRACT Cytasters were induced in the unfertilized eggs of the sea urchin Lytechinus pictus by two different methods: (1) treatment with hexylene glycol or taxol, which are known to lower the tubulin critical concentration in vitro , but do not activate...
Journal Articles
J Cell Sci (1992) 102 (1): 91–102.
Published: 1 May 1992
..., and in taxol-treated mitotic cells, that the SPN antigen is involved in organizing the microtubules of the spindle. The 210 kDa protein defined as SPN antigen relocates from the nuclear matrix to the centrosome at prophase, remains associated with the poles at metaphase and anaphase, and dissociates from...
Journal Articles
J Cell Sci (1991) 100 (3): 533–540.
Published: 1 November 1991
... antibody. This allowed us to compare the subcellular distribution of three kinds of centrosomal antigens in a single cell. Mitotic PtKi cells treated with either nocodazole or taxol included microtubule-containing cytoplasmic foci and parallel bundles of short microtubules at the cell periphery. All...
Journal Articles