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Keywords: Taxol
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Journal Articles
J Cell Sci (2009) 122 (15): 2579–2585.
Published: 01 August 2009
... chemotherapy forms the mainstay of cancer treatment, and agents that disrupt mitotic spindle assembly – so called `anti-mitotics' – are commonly used to treat a wide variety of cancers. Traditional anti-mitotic agents include the microtubule toxins such as taxol, other taxanes and the vinca alkaloids, all...
Journal Articles
J Cell Sci (2009) 122 (14): 2337–2350.
Published: 15 July 2009
... ; llewelyn.roderick@bbsrc.ac.uk ) © The Company of Biologists Limited 2009 2009 Calcium Gene transcription Ins P 3 Nucleus Paclitaxel Ryanodine Signalling Spindle checkpoint Taxol Calcium (Ca 2+ ) is a key player in signal transduction. It modulates diverse cellular activities ranging from...
Journal Articles
J Cell Sci (2001) 114 (21): 3885–3897.
Published: 01 November 2001
... to substantially reduce the level of ATP in living cells and we used Taxol to halt microtubule dynamics. Both treatments slowed the dynamics of 5×GFP-EMTB speckles observed by FSM. We also used fluorescence recovery after photobleaching (FRAP) to quantify the half-time of binding and dissociation of the 5×GFP-EMTB...