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Keywords: Tauopathy
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J Cell Sci (2023) 136 (12): jcs261223.
Published: 21 June 2023
... characteristics such as reversals regulate cargo transport by modulating the proportion of SCs along the neuronal process. These predictions from simulations were validated by experiments conducted on a C. elegans tauopathy model, with implications for the progression of neurodegenerative diseases. We...
Includes: Supplementary data
Journal Articles
J Cell Sci (2005) 118 (2): 397–408.
Published: 15 January 2005
... hyperphosphorylated and aggregated in a number of neurodegenerative diseases referred to as tauopathies. In this study, we identify and compare the residues in human Tau phosphorylated in vitro by all four p38 MAPK isoforms, and study the regulation of the phosphorylation of Thr50, under conditions where p38 MAPKs...
Journal Articles
J Cell Sci (2000) 113 (8): 1373–1387.
Published: 15 April 2000
...Garth F. Hall; Boyang Chu; Gloria Lee; Jun Yao ABSTRACT The intracellular accumulation of tau protein and its aggregation into filamentous deposits is the intracellular hallmark of neurofibrillary degenerative diseases such as Alzheimer’s Disease and familial tauopathies in which tau is now thought...