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Keywords: Tankyrase
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Journal Articles
J Cell Sci (2023) 136 (20): jcs261214.
Published: 27 October 2023
..., is degraded through tankyrase. Consequently, tankyrase small-molecule inhibitors block Wnt signaling by stabilizing axin, revealing potential for cancer therapy. Here, we discovered that axin is phosphorylated by casein kinase 1 alpha 1 (CSNK1A1, also known as CK1α) at an N-terminal casein kinase 1 consensus...
Includes: Supplementary data
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Proteostasis
J Cell Sci (2022) 135 (14): jcs259638.
Published: 27 July 2022
... with tankyrase-1/2 (encoded by TNKS and TNKS2 ). Overall, this study provides critical insights into CTLH complex function and composition in both the cytoplasm and nucleus. * Author for correspondence ( [email protected] ) Handling Editor: John Heath Competing interests The authors...
Includes: Supplementary data
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Adhesion
J Cell Sci (2016) 129 (18): 3396–3411.
Published: 15 September 2016
...-to-mesenchymal transitions and as a tumour suppressor. Although the functional role of the Crumbs complex is being elucidated, its regulation is poorly understood. Here, we show that suppression of RNF146, an E3 ubiquitin ligase that recognizes ADP-ribosylated substrates, and tankyrase, a poly(ADP-ribose...
Includes: Supplementary data
Journal Articles
J Cell Sci (1999) 112 (21): 3649–3656.
Published: 1 November 1999
...Susan Smith; Titia de Lange ABSTRACT Tankyrase is a human poly(ADP-ribose) polymerase that was initially identified through its interaction with the telomeric protein TRF1, a negative regulator of telomere length. In vitro poly(ADP-ribosyl)ation by tankyrase inhibits TRF1 binding to telomeric DNA...