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Keywords: Talin
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Journal Articles
J Cell Sci (2024) 137 (9): jcs262116.
Published: 16 May 2024
...Wei Wang; Paul Atherton; Maaike Kreft; Lisa te Molder; Sabine van der Poel; Liesbeth Hoekman; Patrick Celie; Robbie P. Joosten; Reinhard Fässler; Anastassis Perrakis; Arnoud Sonnenberg ABSTRACT Talin (herein referring collectively to talin 1 and 2) couples the actomyosin cytoskeleton to integrins...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
J Cell Sci (2023) 136 (8): jcs260746.
Published: 21 April 2023
... to the actomyosin cytoskeleton, via cytoplasmic proteins. Adhesion depends on the activation of integrins. Talin and kindlin proteins are intracellular activators of integrins that bind to β-integrin cytoplasmic tails. Integrin activation and clustering through extracellular ligands guide the organization...
Includes: Supplementary data
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Mechanobiology
J Cell Sci (2022) 135 (22): jcs259769.
Published: 18 November 2022
... of mechanical linkages to mechanochemical switches that enables conversion of forces into biological signals. Mechanotransduction Mechanosensing Motor proteins Cytoskeleton Disease-associated mutations Talin Force-dependent switches Academy of Finland http://dx.doi.org/10.13039...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (20): jcs258749.
Published: 28 October 2021
...Benjamin T. Goult; Nicholas H. Brown; Martin A. Schwartz ABSTRACT Talins are cytoskeletal linker proteins that consist of an N-terminal head domain, a flexible neck region and a C-terminal rod domain made of 13 helical bundles. The head domain binds integrin β-subunit cytoplasmic tails, which...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
J Cell Sci (2021) 134 (6): jcs254359.
Published: 29 March 2021
..., β1 integrin and paxillin. We examined how these interactions enable vimentin to regulate cell migration on collagen. In fibroblasts, depletion of vimentin increased talin-dependent activation of β1 integrin by more than 2-fold. Loss of vimentin was associated with reduction of β1 integrin clustering...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2019) 132 (21): jcs235531.
Published: 1 November 2019
...Thomas Bromberger; Liang Zhu; Sarah Klapproth; Jun Qin; Markus Moser ABSTRACT Recruitment and tethering of talin to the plasma membrane initiate the process of integrin activation. Multiple factors including the Rap1 proteins, RIAM (also known as APBB1IP) and PIP 2 bind talin proteins and have been...
Includes: Supplementary data
Journal Articles
Journal Articles
In collection:
Adhesion
J Cell Sci (2018) 131 (24): jcs225144.
Published: 18 December 2018
...Darius Camp; Amanda Haage; Veronika Solianova; William M. Castle; Qinyuan A. Xu; Emily Lostchuck; Benjamin T. Goult; Guy Tanentzapf ABSTRACT Attachment of cells to the extracellular matrix (ECM) via integrins is essential for animal development and tissue maintenance. The cytoplasmic protein Talin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (21): 3764–3775.
Published: 1 November 2017
...Juan Gao; Ming Huang; Jingjing Lai; Kaijun Mao; Peisen Sun; Zhongyuan Cao; Youpei Hu; Yingying Zhang; Marie L. Schulte; Chaozhi Jin; Jian Wang; Gilbert C. White; Zhen Xu; Yan-Qing Ma ABSTRACT Kindlins play an important role in supporting integrin activation by cooperating with talin; however...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
J Cell Sci (2017) 130 (15): 2435–2446.
Published: 1 August 2017
...Benjamin Klapholz; Nicholas H. Brown ABSTRACT Talin has emerged as the key cytoplasmic protein that mediates integrin adhesion to the extracellular matrix. In this Review, we draw on experiments performed in mammalian cells in culture and Drosophila to present evidence that talin is the most...
Journal Articles
In collection:
Adhesion
J Cell Sci (2017) 130 (9): 1612–1624.
Published: 1 May 2017
... (FLAP) experiments, we found that the mobility of core FA proteins correlates with their function. Structural proteins such as tensin, talin and vinculin are significantly less mobile in FAs than signaling proteins such as FAK (also known as PTK2) and paxillin. The mobilities of the structural proteins...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (1): 152–163.
Published: 1 January 2017
... growth in vivo . Thus, Rap1 mediates the effects of increased extracellular tension in multiple ways that are capable of contributing to tumor progression when dysregulated. Once vinculin binds to talin at focal adhesions, it can undergo tension-mediated stretching and straightening, a process...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
J Cell Sci (2016) 129 (23): 4354–4365.
Published: 1 December 2016
... is the talin-binding D1 domain, and this appears to require talin-binding activity, as lethality was suppressed by competition with single vinculin-binding sites from talin. Activated Drosophila vinculin triggered the formation of cytoplasmic adhesion complexes through the rod of talin, but independently...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
J Cell Sci (2016) 129 (10): 2030–2042.
Published: 15 May 2016
... of H-Ras signaling. H-Ras converted filamentous vimentin into aggregates near the nucleus, where no integrin binding can occur. In addition, an increase in the amount of vimentin filaments accessible to the integrin β3 tail enhanced talin-induced integrin binding to its ligands by inducing integrin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (9): 1718–1731.
Published: 1 May 2015
...Jiafu Liu; Zhengli Wang; Aye Myat Myat Thinn; Yan‐Qing Ma; Jieqing Zhu Studies on the mechanism of integrin inside‐out activation have been focused on the role of β‐integrin cytoplasmic tails, which are relatively conserved and bear binding sites for the intracellular activators including talin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (21): 4634–4644.
Published: 1 November 2014
... that 12 are required in developing adult muscles, consistent with roles downstream of Notch. Focusing on three, Reck , rhea / talin and trio , we verify their expression in adult muscle progenitors and identify Notch-regulated enhancers in each. Full activity of these enhancers requires functional binding...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2012) 125 (14): 3271–3280.
Published: 15 July 2012
... of cytoplasmic proteins, such as talins and kindlins, to the cytoplasmic tail of β-integrins is widely accepted as being the crucial step in integrin activation. By contrast, much less is known with regard to the counteracting mechanism involved in switching integrins into an inactive conformation...
Journal Articles
J Cell Sci (2011) 124 (11): 1844–1856.
Published: 1 June 2011
... attachment to the extracellular matrix (ECM), connect to the intracellular environment through the cytoplasmic adapter protein talin. Talin has two essential functions: orchestrating the assembly of the intracellular adhesion complex (IAC), which associates with integrin, and regulating the affinity...
Includes: Supplementary data