...Ratnakar Potla; Mariko Hirano-Kobayashi; Hao Wu; Hong Chen; Akiko Mammoto; Benjamin D. Matthews; Donald E. Ingber ABSTRACT One of the most rapid (less than 4 ms) transmembrane cellular mechanotransduction events involves activation of transient receptor potential vanilloid 4 (TRPV4) ion channels...

...Takatoshi Karasawa; Qi Wang; Yi Fu; David M. Cohen; Peter S. Steyger The cochlea and kidney are susceptible to aminoglycoside-induced toxicity. The non-selective cation channel TRPV4 is expressed in kidney distal tubule cells, and hair cells and the stria vascularis in the inner ear. To determine...

... of volume, a process called regulatory volume decrease (RVD). A possible participant in RVD is the non-selective cation channel TRPV4, a member of the TRP superfamily that has been shown to react to hypotonic stimuli with a conductance for Ca 2+ . As a model for cell-volume regulation, we used a human...