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Keywords: TPX2
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Journal Articles
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Cytoskeleton
J Cell Sci (2021) 134 (4): jcs258356.
Published: 19 February 2021
... that the spindle assembly factor TPX2 regulates astral microtubules. TPX2 in the spindle pole area is activated by GM130 (GOLGA2) on Golgi membranes to promote astral microtubule growth. GM130 relieves TPX2 inhibition by competing for importin α1 (KPNA2) binding. Mitotic phosphorylation of importin α at serine 62...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (12): jcs243071.
Published: 16 June 2020
...Ahmed Abdelbaki; H. Begum Akman; Marion Poteau; Rhys Grant; Olivier Gavet; Giulia Guarguaglini; Catherine Lindon ABSTRACT Activity of AURKA is controlled through multiple mechanisms including phosphorylation, ubiquitin-mediated degradation and allosteric interaction with TPX2. Activity peaks...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2011) 124 (1): 113–122.
Published: 1 January 2011
... in G2 and M phases, followed by regulated proteolysis at the end of mitosis. The microtubule-binding protein TPX2 plays a major role in regulating the activity and localisation of Aurora-A in mitotic cells. Here, we report a novel regulatory role of TPX2 and show that it protects Aurora-A from...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (22): 3978–3988.
Published: 15 November 2010
... . Barr A. R. , Gergely F. ( 2007 ). Aurora-A: the maker and breaker of spindle poles . J. Cell Sci. 120 , 2987 - 2996 . Bayliss R. , Sardon T. , Vernos I. , Conti E. ( 2003 ). Structural basis of Aurora-A activation by TPX2 at the mitotic spindle . Mol. Cell...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2009) 122 (5): 644–655.
Published: 1 March 2009
... contractility provides the impetus for Ran release and, consequently, microtubule assembly is blocked in blebbistatin- and Y27632-treated apoptotic cells. Importantly, the spindle-assembly factor TPX2 (targeting protein for Xklp2), colocalises with apoptotic microtubules, and siRNA silencing of TPX2...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2006) 119 (20): 4143–4153.
Published: 15 October 2006
... is not completely eliminated under these conditions. This suggests that other proteins can act as MT nucleators. Recent work has implicated members of three types of MT-associated proteins in MT nucleation: TACCs (transforming acidic coiled coil proteins), TOGs (tumor overexpressed genes) and TPX2 (targeting...
Journal Articles