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Keywords: TNF-α
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Journal Articles
J Cell Sci (2020) 133 (14): jcs239814.
Published: 24 July 2020
.... COPII Rab1 ERES TNF-α MANII RUSH The endoplasmic reticulum (ER) serves as the entry point for the secretory pathway. Following successful translation and translocation, secretory proteins synthesized in the ER are concentrated by COPII proteins at ER exit sites (ERES) and trafficked...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (17): 4037–4047.
Published: 01 September 2013
... RAW264.7 cells treated with lipopolysaccharide (LPS) exhibited markedly reduced efferocytic activity, but this was restored by co-incubation with RvD1. RvD1-induced restoration of the efferocytic activity appears to be mediated by downregulation of LPS-induced TNF-α expression. The inhibitory effect...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (19): 4620–4629.
Published: 01 October 2012
... for AIMP1 that mediates the secretion of TNF-α from THP-1 monocytic cells and primary human peripheral blood mononuclear cells (PBMCs). In a screen of 499 soluble receptors we identified CD23, a known low-affinity receptor for IgE, as a high affinity binding partner of AIMP1. We found that downregulation...
Journal Articles
J Cell Sci (2012) 125 (9): 2160–2171.
Published: 01 May 2012
...Christina Böhm; Anja Derer; Roland Axmann; Ulrike Hillienhoff; Mario M. Zaiss; Julia Luther; Christine Zech; Michael Stock; Carina Scholtysek; Klaus Engelke; Andreas Hess; Jan P. Tuckermann; Georg Schett; Jean-Pierre David Tumor necrosis factor (TNF)-α is a key cytokine regulator of bone...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (21): 3665–3675.
Published: 01 November 2011
...Jianwei Ren; Yu Wang; Yun Gao; Shalin B. K. Mehta; Caroline G. L. Lee Tumor necrosis factor-alpha (TNF-α) plays important roles in chronic inflammation-associated tumorigenesis but the mechanisms involved remain poorly understood. Previously, we reported that high levels of FAT10 led to chromosomal...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (15): 2552–2560.
Published: 01 August 2011
... as a result of loss of NCAM function. Furthermore, insulin resistance of Ncam −/− MSCs was shown to be associated with induction of tumor necrosis factor α (TNF-α), a key mediator of insulin resistance. Finally, we demonstrated that re-expression of NCAM-180, but not NCAM-140, inhibits induction of TNF-α...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (10): 1616–1625.
Published: 15 May 2009
... al., 1999 ; Nottebaum et al., 2008 ), the latter interaction also being targeted by TNF-α. Therefore, we cannot rule out that TP-induced signalling mechanisms in addition to enhanced transinteraction may contribute to the protective effects of TP in vivo and in vitro. However, these effects of TP...
Journal Articles
J Cell Sci (2007) 120 (4): 692–701.
Published: 15 February 2007
... activates p38 and myogenesis through stimulating TNF-α release by TNF-α converting enzyme (TACE). In C2C12 or mouse primary myoblasts cultured in growth medium, static stretch activated p38 along with ERK1/2, JNK and AKT. Disrupting TNF-α signaling by TNF-α-neutralizing antibody or knocking out TNF-α...
Journal Articles
J Cell Sci (2006) 119 (14): 2985–2994.
Published: 15 July 2006
...-α), the key mediator of inflammation, which was reported to induce cell transformation in mouse epidermal Cl41 cells. In this study, we demonstrated that TNF-α was able to induce NFAT activation, as well as the expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS...
Journal Articles
J Cell Sci (2005) 118 (14): 3203–3212.
Published: 15 July 2005
... encoding TNF-α, linked to the luciferase-encoding gene luc ( Decker et al., 2003 ). Reporter construct pTNF-Luc represents three copies of the overlapping EGR-1, Sp1 and the NFAT sites of the TNF-α-encoding-gene promoter region (–174 to –143) linked to the luc gene. This promoter fragment was generated...
Journal Articles
J Cell Sci (2005) 118 (10): 2143–2153.
Published: 15 May 2005
... activity around stromal cells in cocultures and xenografted tumors. Use of Smad3 knockout fibroblasts, small molecule inhibitors, and neutralizing antibodies showed that MMP-9 expression was induced by tumor cell-derived TNF-α and TGF-β, dependent on Smad-, Ras-, and PI3-kinase-signaling, and likewise...
Includes: Supplementary data
Journal Articles
J Cell Sci (2004) 117 (22): 5197–5208.
Published: 15 October 2004
... lymphopoiesis, adaptive immunity, oncogenesis and cancer chemoresistance. During an inflammatory response, NF-κB activation antagonizes apoptosis induced by tumor necrosis factor (TNF)-α, a protective activity that involves suppression of the Jun N-terminal kinase (JNK) cascade. This suppression can involve...
Journal Articles
J Cell Sci (2003) 116 (17): 3591–3600.
Published: 01 September 2003
.... It was found that stimulation of the HMEC-1 microvascular endothelial cell line with the pro-inflammatory cytokines IFN-γ and TNF-α caused a transient decrease in the level of NDST-1 and -2 transcripts after 4 hours ( P <0.05 and P <0.01 respectively), but the expression of NDST-1 increased above control...