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Keywords: TLR4
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Journal Articles
J Cell Sci (2019) 132 (17): jcs228700.
Published: 05 September 2019
... PPE39 on DCs was mediated by TLR4 through downstream MAPK and NF-κB signaling pathways. Moreover, PPE39-treated DCs promoted naïve CD4 + T-cell proliferation accompanied by remarkable increases of IFN-γ and IL-2 secretion levels, and an increase in the Th1-related transcription factor T-bet but not in...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (22): 4096–4111.
Published: 15 November 2015
...Agnieszka Płóciennikowska; Mykola I. Zdioruk; Gabriela Traczyk; Anna Świątkowska; Katarzyna Kwiatkowska ABSTRACT Bacterial lipopolysaccharide (LPS) induces strong pro-inflammatory reactions after sequential binding to CD14 protein and TLR4 receptor. Here, we show that CD14 controls generation of...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (10): 1982–1990.
Published: 15 May 2015
...Deepthi Menon; Rebecca Coll; Luke A. J. O'Neill; Philip G. Board ABSTRACT Macrophages mediate innate immune responses that recognise foreign pathogens, and bacterial lipopolysaccharide (LPS) recruits a signalling pathway through Toll-like receptor 4 (TLR4) to induce pro-inflammatory cytokines and...
Includes: Supplementary data
Journal Articles
J Cell Sci (2002) 115 (12): 2603–2611.
Published: 15 June 2002
... lipopolysaccharide (LPS)-cellular activation, such as CD14, heat shock protein(hsp) 70, 90, Chemokine receptor 4 (CXCR4), growth differentiation factor 5(GDF5) and Toll-like receptor 4 (TLR4), are present in microdomains following LPS stimulation. Lipid raft integrity is essential for LPS-cellular activation, since...