... in the absence of PTP1B ( Fig. 2 F), consistent with our observations following TLR stimulation. In line with these results, levels of secreted IL6 upon cGAMP stimulation or MCMV infection were unaffected in PTP1B −/− BMDMs compared to those seen in WT BMDMs ( Fig. S1B ). To ensure that the reduced type I IFN...

...Lin Luo; Richard M. Lucas; Liping Liu; Jennifer L. Stow; Ana-Maria Lennon-Duménil ABSTRACT Toll-like receptors (TLRs) are danger-sensing receptors that typically propagate self-limiting inflammatory responses, but can unleash uncontrolled inflammation in non-homeostatic or disease settings...

...Peter Ulrichts; Celia Bovijn; Sam Lievens; Rudi Beyaert; Jan Tavernier; Frank Peelman Toll-like receptors (TLRs) are crucial components of innate immunity, ensuring efficient responses against invading pathogens. After ligand binding, TLR signaling is initiated by recruitment of adaptor molecules...

... 2008 2008 COT TNF MAP kinase TACE TLR Tumour necrosis factor α (TNFα) is a key player in inflammatory disorders ( Choy and Panayi, 2001 ; Russo and Polosa, 2005 ), and agents that bind to and inactivate TNFα in the circulation have been approved for the treatment of these diseases...