... ( [email protected] ; [email protected] ) 12 4 2012 © 2012. Published by The Company of Biologists Ltd 2012 ECM Filamin Matrix metalloproteinase MMP TIMP Filamins (FLNs) are an important family of conserved actin-binding proteins with essential roles in development...

...Andrew H. Baker; Dylan R. Edwards; Gillian Murphy Tissue inhibitors of metalloproteinases (TIMPs) are the major cellular inhibitors of the matrix metalloproteinase (MMP) sub-family, exhibiting varying efficacy against different members, as well as different tissue expression patterns and modes...

..., completely abrogated shedding. The metalloproteinase mediating Met cleavage was specifically inhibited by the tissue inhibitor of metalloproteinases (TIMP)-3, but not by TIMP-1 or TIMP-2. Furthermore, the level of Met shedding could be modulated by different cell-matrix interactions. Our results indicate...

... out to demonstrate that stromelysin binding was through this domain. By use of an antiserum to the tissue inhibitor of metalloproteinases (TIMP) it was shown that TIMP is unable to bind to reconstituted collagen fibrils. TIMP, however, will bind when active high M r stromelysin is present...

...Jelena Gavrilovic; Rosalind M. Hembry; John J. Reynolds; Gillian Murphy ABSTRACT A specific antiserum to purified rabbit tissue inhibitor of metalloproteinases (TIMP) was raised in sheep, characterized and used to investigate the role of TIMP in a model system. Chondrocytes and endothelial cells...

...Rosalind M. Hembry; Gillian Murphy; John J. Reynolds ABSTRACT A specific antiserum to pure human amniotic fluid metalloproteinase inhibitor (TIMP) was raised in a sheep. This antiserum was used to demonstrate: firstly, the immunological identity of the TIMP activities from amniotic fluid...