... favoured PSS (increasing VEGF xxx ) whereas TGFβ1 favoured DSS, increasing VEGF xxx b levels. TGFβ1 induced DSS selection was prevented by inhibition of p38 MAPK and the Clk/sty (CDC-like kinase, CLK1) splicing factor kinase family, but not ERK1/2. Clk phosphorylates SR protein splicing factors ASF/SF2...

...Michelle E. Diamond; Limin Sun; Adam J. Ottaviano; Mathew J. Joseph; Hidayatullah G. Munshi Aberrant expression of N-cadherin is associated with tumor progression in squamous cell carcinomas (SCCs). Consequently, we examined the regulation of N-cadherin by TGFβ1, an important mediator...

... of caspase-3 and caspase-8. The consequence of CD105 upregulation was revealed using an antisense approach and a TUNEL assay. Suppression of CD105 increased cell apoptosis under hypoxic stress in the absence of TGFβ1. Furthermore,hypoxia and TGFβ1 synergistically induced apoptosis in the CD105-deficient...

...Sonja Boland; Emmanuelle Boisvieux-Ulrich; Odile Houcine; Armelle Baeza-Squiban; Marcel Pouchelet; Damien Schoëvaërt; Francelyne Marano ABSTRACT In the present study we have investigated the effects of transforming growth factor β (TGFβ1) on rabbit tracheal epithelial cells in primary culture...

... protein with the immune complex. This observation suggests that interference with the cell cycle may commence in late S or G 2 . * Author for correspondence 09 05 1994 24 08 1994 © 1994 by Company of Biologists 1994 TGFβ1 growth inhibition Type β transforming growth...

...E. J. Sanders; S. Prasad ABSTRACT We have examined the immunocytochemical distribution of TGFβ1 (transforming growth factor β 1) in the gastrulating chick embryo, and have correlated the results with the ability of this factor to promote in vitro changes in the phenotype of mesoderm and epiblast...