... intracellular pathogens is of utmost significance. Pathogenic intrusion activates autophagy and phagocytic pathways that culminate in the lysosome, a vital organelle responsible for pathogen clearance. The transcription factor TFEB plays a pivotal role in autophagy-lysosomal function. Although TFEB...

...Toshiharu Fujita; Sayaka Kubo; Tatsuya Shioda; Ayaka Tokumura; Satoshi Minami; Megumi Tsuchiya; Yoshitaka Isaka; Hidesato Ogawa; Maho Hamasaki; Li Yu; Tamotsu Yoshimori; Shuhei Nakamura ABSTRACT TFEB, a basic helix-loop-helix transcription factor, is a master regulator of autophagy, lysosome...

... hepatoma and HeLa cells. Specifically, we identify that Rab32 supports the mechanistic target of rapamycin complex 1 (mTORC1) signaling under basal and amino acid-stimulated conditions. Consistent with inhibited mTORC1, an increase in nuclear TFEB localization and lysosome biogenesis is also observed...

...Gennaro Napolitano; Andrea Ballabio ABSTRACT The transcription factor EB (TFEB) plays a pivotal role in the regulation of basic cellular processes, such as lysosomal biogenesis and autophagy. The subcellular localization and activity of TFEB are regulated by mechanistic target of rapamycin (mTOR...

.... MITF TFEB TORC1 Gut Melanocytes v-ATPase The vacuolar (H + )-ATPase (v-ATPase) is an evolutionarily conserved holoenzyme that controls basic cellular processes in eukaryotic cells. As an ATP-dependent proton pump, it acidifies intracellular or extracellular compartments and generates...