...Jessie Chen; Yung-Hsu Tsai; Anne K. Linden; John A. Kessler; Chian-Yu Peng ABSTRACT WW domain-containing transcription regulator 1 (WWTR1, referred to here as TAZ) and Yes-associated protein (YAP, also known as YAP1) are transcriptional co-activators traditionally studied together as a part...

...Soma Tripathi; Tetsuaki Miyake; Jonathan Kelebeev; John C. McDermott ABSTRACT Hippo signaling in Drosophila and mammals is prominent in regulating cell proliferation, death and differentiation. Hippo signaling effectors (YAP and TAZ; also known as YAP1 and WWTR1, respectively) exhibit crosstalk...

... regulators YAP1 and TAZ (also known as WWTR1) on the surface of mitochondria and to reversibly release them upon blue light illumination. After dissociation, fluorescent signals from the mitochondria, cytoplasm and nucleus are extracted by a bespoke app and used to generate rates of nuclear entry and exit...

... of Drosophila imaginal discs . J. Exp. Zool.   222 , 97 - 102 . 10.1002/jez.1402220113 Miesfeld , J. B. , Gestri , G. , Clark , B. S. , Flinn , M. A. , Poole , R. J. , Bader , J. R. , Besharse , J. C. , Wilson , S. W. and Link , B. A. ( 2015 ). Yap and Taz...

... revealed that VGLL3 bound TEAD1, TEAD3 and TEAD4 in myoblasts and/or myotubes. However, there was no interaction with proteins from major regulatory systems such as the Hippo kinase cascade, unlike what is found for the TEAD co-factors YAP (encoded by YAP1 ) and TAZ (encoded by WWTR1 ). Vgll3...

... transcription factors and their transcriptional co-activators Yap and Taz have been previously implicated in promoting an EMT; however, their direct transcriptional target genes and their functional role during EMT have remained elusive. We have uncovered a previously unanticipated role of the transcription...