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Keywords: TACE
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Journal Articles
Journal Articles
J Cell Sci (2013) 126 (19): 4349–4357.
Published: 1 October 2013
... regulator of myogenesis, via activating TNFα-converting enzyme (TACE, also known as ADAM17), to release autocrine TNFα. However, the signaling mechanism of mechanical activation of TACE is unknown. Because TACE possesses the structural features of substrates of the non-receptor tyrosine kinase Src, we...
Journal Articles
J Cell Sci (2008) 121 (2): 149–154.
Published: 15 January 2008
... and that this is prevented by inhibition of MAPK kinases 1 and 2 (MKK1/2) or in TPL2-deficient macrophages. However, the transport of pre-TNFα from the Golgi to the plasma membrane is unaffected by inhibition of the TPL2-MKK1/2-ERK1/2 pathway. Finally, we show that TACE, the protease that cleaves pre-TNFα to secreted TNFα...
Journal Articles
J Cell Sci (2007) 120 (4): 692–701.
Published: 15 February 2007
... activates p38 and myogenesis through stimulating TNF-α release by TNF-α converting enzyme (TACE). In C2C12 or mouse primary myoblasts cultured in growth medium, static stretch activated p38 along with ERK1/2, JNK and AKT. Disrupting TNF-α signaling by TNF-α-neutralizing antibody or knocking out TNF-α...
Journal Articles
J Cell Sci (2005) 118 (5): 1061–1070.
Published: 1 March 2005
... their intracellular Golgi-complex-associated pool towards the plasma membrane. This results in their enhanced cleavage by TNF-α converting enzyme (TACE) because it is reduced by synthetic metalloprotease inhibitors, recombinant TIMP-3 and by a dominant negative form of TACE. In the presence of TACE inhibitor...
Journal Articles
J Cell Sci (2003) 116 (10): 1949–1957.
Published: 15 May 2003
...Franck Peiretti; Paule Deprez-Beauclair; Bernadette Bonardo; Hélène Aubert; Irène Juhan-Vague; Gilles Nalbone Tumor necrosis factor alpha converting enzyme (TACE) is the metalloprotease-disintegrin responsible for the ectodomain shedding of several proteins, including tumor necrosis factor α...