... of mechanical signals in modulating adaptive immunity. T lymphocytes B lymphocytes Mechanosensing Cytoskeletal forces Signaling Mechanoimmunology National Institutes of Health R35 GM145313 National Science Foundation http://dx.doi.org/10.13039/100000001 PHY 1915534...

... leading to T lymphocyte activation is triggered. Here, we show that another signaling region can be detected before formation of the synapse at the opposite pole of the T cell. This structure appears during the first minute after the contact forms, is transient and contains all the classic components...

... processes such as adhesion, T lymphocyte activation and phagocytosis through its interaction with β2 integrins. To investigate the role of cathepsin X in the migration of T lymphocytes, Jurkat T lymphocytes were stably transfected with a pcDNA3 expression vector containing cathepsin X cDNA. The cathepsin-X...

...Alix Delaguillaumie; Cécile Lagaudrière-Gesbert; Michel R. Popoff; Hélène Conjeaud Activation of T lymphocytes requires the engagement of the T-cell receptor and costimulation molecules through cell-to-cell contacts. The tetraspanin CD82 has previously been shown to act as a cytoskeleton...

... the usual diffuse nucleoplasmic labelling, 40-60% of nuclei in heated samples also contained numerous bright spots. We then examined whether the heterogeneity in NuMA organization might be an indication of a differential response of B and T lymphocytes to hyperthermia, and whether the presence of NuMA spots...

... mechanisms whereby multiple GATA factors expressed in a single cell might be used to elicit differential transcriptional activities. * Author for correspondence © The Company of Biologists Limited 1992 1992 globin gene switching GATA transcription factor T lymphocytes HIV During...

...Kuo-Li P. Sung; Lanping A. Sung; Mary Crimmins; Steven J. Burakoff; Shu Chien ABSTRACT The biophysical properties of cytotoxic T lymphocytes during the killing of their target cells was investigated by using a human cytotoxic T lymphocyte clone, Fl, and the target cell, JY, for which it is specific...