...Mariana Castro Dias; Adolfo Odriozola Quesada; Sasha Soldati; Fabio Bösch; Isabelle Gruber; Tobias Hildbrand; Derya Sönmez; Tejas Khire; Guillaume Witz; James L. McGrath; Jörg Piontek; Masuo Kondoh; Urban Deutsch; Benoît Zuber; Britta Engelhardt ABSTRACT The migration of activated T cells across...

...://www.biologists.com/user-licence-1-1/ Summary: Cytokines play a main role in the communication between immune cells to eliminate infected of transformed cells. We reveal how cells finely control the intensity of cytokine signaling. Cytokine Interleukin Receptor Interaction T cells NK cells...

... a functional PX domain that is important for endosome binding, but it is the only sorting nexin with a PDZ domain. We identified SNX27 as a partner of diacylglycerol kinase ζ (DGKζ), a negative regulator of T cell function that metabolises diacylglycerol to yield phosphatidic acid. SNX27 interacts...

... of monocytes with patrolling behavior. Science 317 , 666 -670. Bajenoff, M., Granjeaud, S. and Guerder, S. ( 2003 ). The strategy of T cell antigen-presenting cell encounter in antigen-draining lymph nodes revealed by imaging of initial T cell activation. J. Exp. Med. 98 , 715 -724. Bajenoff...

...Sarah Russell The differentiation, activation and expansion of T cells are dictated by their integrated response to a complex array of extracellular signals. Recent studies provide insight into how these signals are integrated and demonstrate a key role for cell shape in many aspects of T-cell...

... of T cells induced by SDF-1α, and in the inhibition of the HIV-1-Env antifusogenic activity of this chemokine. Coimmunoprecipitation and protein-protein binding studies demonstrated that MIIA interacts with both the cytoplasmic tail of CXCR4 and β-arrestin. Moreover, SDF-1α promotes a rapid MIIA-β...

...Yanping Huang; Janis K. Burkhardt Following stimulation, T cells undergo marked changes in actin architecture that are required for productive immune responses. T-cell-receptor-dependent reorganization of the actin cytoskeleton is necessary for the formation of the immunological synapse at the T...

... in immune regulation, such as the T cell receptor in immune synapses (for a review, see Alonso and Millan, 2001 ). Similar to actin reorganization, the localization of CD95 to lipid raft aggregates after receptor triggering does not seem to be important for apoptotic signaling, as cytD-mediated inhibition...

... transport in epithelial cells. T cell activation induces a rapid compartmentalisation of signalling machinery into reorganised rafts that are used as platforms for the assembly of the signalling complex. Costimulatory molecules participate in this process by providing signals that mobilise raft lipids...