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Keywords: Systems biology
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Journal Articles
J Cell Sci (2013) 126 (9): 1913–1921.
Published: 01 May 2013
.... F. ( 2007 ). Proteins, drug targets and the mechanisms they control: the simple truth about complex networks.   Nat. Rev. Drug Discov.   6 , 871 – 880 . 10.1038/nrd2381 Arkin   A. P. , Schaffer   D. V. ( 2011 ). Network news: innovations in 21st century systems biology.   Cell...
Journal Articles
J Cell Sci (2012) 125 (17): 4103–4113.
Published: 01 September 2012
... ) 19 4 2012 © 2012. Published by The Company of Biologists Ltd 2012 Constraint interaction networks Cytokinesis Protein interaction Split–Ubiquitin Systems biology To separate mother from daughter, yeast cells undergo a well-orchestrated set of biochemical reactions...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (1): 82–90.
Published: 01 January 2011
... RCAN1. * These authors contributed equally to this work ‡ Authors for correspondence ( wdheo@kaist.ac.kr ; ckh@kaist.ac.kr ) 15 9 2010 © 2011. 2011 Systems biology Calcineurin–NFAT signaling pathway RCAN1 Incoherent regulation switch Cardiac hypertrophy Mathematical...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2011) 124 (1): 35–46.
Published: 01 January 2011
... Constraint interaction network Protein–protein interaction Organelle inheritance Polarized growth Protein kinase Protein phosphatase Systems biology Inactivation of proteins that participate in more than one cellular process leads to a variety of apparently unconnected phenotypes. Understanding...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (16): 2834–2843.
Published: 15 August 2010
... mechanistic understanding of physiological TNFα activation of inflammatory responses in cells and tissues. * Author for correspondence ( m.white@liv.ac.uk ) 26 5 2010 © 2010. 2010 NF-κB TNFα Live-cell imaging Stochastic processes Mathematical modelling Systems biology...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (3): 425–435.
Published: 01 February 2009
... slightly increased the amplitude and duration of ERK activation. Removal of RKIP had similar effects ( Fig. 4B ). Systems biology ERK signaling pathway RKIP Feedback regulation Dynamics Mathematical modeling Signal transduction through the Ras-Raf-MEK-ERK pathway (or ERK pathway for short...
Journal Articles
J Cell Sci (2008) 121 (1): 55–64.
Published: 01 January 2008
... Biophysical modelling Domain formation Membrane traffic Systems biology Protein transport along the secretory pathway is initiated by the formation of small coated vesicles at the endoplasmic reticulum (ER). The core machinery for shaping these vesicles are the COPII proteins ( Barlowe et al., 1994...
Includes: Supplementary data
Journal Articles
J Cell Sci (2005) 118 (21): 4947–4957.
Published: 01 November 2005
...-protein interactions Signal transduction Transcriptional regulatory networks Metabolic networks Network modeling Systems biology Genes and gene products interact on several levels. At the genomic level, transcription factors can activate or inhibit the transcription of genes to give mRNAs...