... Discov.   6 , 871 – 880 . 10.1038/nrd2381 Arkin   A. P. , Schaffer   D. V. ( 2011 ). Network news: innovations in 21st century systems biology.   Cell   144 , 844 – 849 . 10.1016/j.cell.2011.03.008 Bajikar   S. S. , Janes   K. A. ( 2012 ). Multiscale models of cell...

... ) 19 4 2012 © 2012. Published by The Company of Biologists Ltd 2012 Constraint interaction networks Cytokinesis Protein interaction Split–Ubiquitin Systems biology To separate mother from daughter, yeast cells undergo a well-orchestrated set of biochemical reactions...

... of RCAN1. * These authors contributed equally to this work ‡ Authors for correspondence ( [email protected] ; [email protected] ) 15 9 2010 © 2011. 2011 Systems biology Calcineurin–NFAT signaling pathway RCAN1 Incoherent regulation switch Cardiac hypertrophy Mathematical...

... Constraint interaction network Protein–protein interaction Organelle inheritance Polarized growth Protein kinase Protein phosphatase Systems biology Inactivation of proteins that participate in more than one cellular process leads to a variety of apparently unconnected phenotypes. Understanding...

... mechanistic understanding of physiological TNFα activation of inflammatory responses in cells and tissues. * Author for correspondence ( [email protected] ) 26 5 2010 © 2010. 2010 NF-κB TNFα Live-cell imaging Stochastic processes Mathematical modelling Systems biology...

[email protected] ; [email protected] ) * These authors contributed equally to this work ‡ Present address: Organon Labs, Newhouse, Motherwell, UK 12 10 2008 © The Company of Biologists Limited 2009 2009 Systems biology ERK signaling pathway RKIP Feedback regulation...

... Biophysical modelling Domain formation Membrane traffic Systems biology Protein transport along the secretory pathway is initiated by the formation of small coated vesicles at the endoplasmic reticulum (ER). The core machinery for shaping these vesicles are the COPII proteins ( Barlowe et al., 1994...

...-mail: [email protected] ) © The Company of Biologists Limited 2005 2005 Protein-protein interactions Signal transduction Transcriptional regulatory networks Metabolic networks Network modeling Systems biology Genes and gene products interact on several levels. At the genomic level...