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Keywords: Synaptotagmin
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Journal Articles
J Cell Sci (2019) 132 (5): jcs221952.
Published: 15 February 2019
...; however, the identity of WPB-associated Ca 2+ -sensors involved in transducing acute increases in [Ca 2+ ] i into granule exocytosis remains unknown. Here, we show that synaptotagmin 5 (SYT5) is expressed in human umbilical vein endothelial cells (HUVECs) and is recruited to WPBs to regulate Ca 2+ -driven...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (12): 2229–2235.
Published: 15 June 2015
...Robyn L. McAdam; Kelly T. Varga; Zhongjiao Jiang; Fiona B. Young; Vanessa Blandford; Peter S. McPherson; Liang-Wei Gong; Wayne S. Sossin ABSTRACT Synaptotagmin 1 (Syt1) is a synaptic vesicle protein that is important for the kinetics of both exocytosis and endocytosis, and is thus a candidate...
Journal Articles
J Cell Sci (2014) 127 (24): 5218–5227.
Published: 15 December 2014
... type II cells. FACE regulates fusion pore expansion and facilitates secretion. However, the mechanisms linking this locally restricted Ca 2+ signal and fusion pore expansion were still elusive. Here, we demonstrate that synaptotagmin-7 (Syt7) is expressed on lamellar bodies and links FACE and fusion...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (13): 3233–3242.
Published: 01 July 2012
..., and presumably the same receptors and substrates with their parental toxins. Here, we report that a mosaic toxin, type D-C (BoNT/D-C), uses different receptors from its parental toxin BoNT/C. BoNT/D-C, but not BoNT/C, binds directly to the luminal domains of synaptic vesicle proteins synaptotagmin (Syt) I and II...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (4): 617–627.
Published: 15 February 2007
...Kara L. Lynch; Thomas F. J. Martin Synaptotagmin I is considered to be a Ca 2+ sensor for fast vesicle exocytosis. Because Ca 2+ -dependent vesicle exocytosis persists in synaptotagmin I mutants, there must be additional Ca 2+ sensors. Multiple synaptotagmin isoforms co-reside on vesicles, which...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2005) 118 (8): 1641–1649.
Published: 15 April 2005
...Yael Haberman; Idit Ziv; Yaara Gorzalczany; Mitsunori Fukuda; Ronit Sagi-Eisenberg Neuronal and non-neuronal tissues show distinctly different intracellular localization of synaptotagmin (Syt) homologues. Therefore, cell type-specific mechanisms are likely to direct Syt homologues to their final...
Journal Articles
J Cell Sci (2005) 118 (7): 1363–1372.
Published: 01 April 2005
...Yafit Atiya-Nasagi; Hila Cohen; Ora Medalia; Mitsunori Fukudan; Ronit Sagi-Eisenberg We have examined the trafficking of synaptotagmin (Syt) I and II in the mast cell line rat basophilic leukemia (RBL-2H3). We demonstrate that both Syt I and Syt II travel through the plasma membrane and require...
Journal Articles
J Cell Sci (2003) 116 (21): 4307–4318.
Published: 01 November 2003
... that synaptotagmin (Syt) IX, a member of the Syt family of proteins, localizes to the ERC and is required for export from the ERC to the cell surface. We demonstrate that rat basophilic leukemia (RBL-2H3) mast cells endogenously express Syt IX mRNA and protein. Localization studies employing fractionation on linear...
Journal Articles
J Cell Sci (2003) 116 (1): 145–154.
Published: 01 January 2003
...Elena Grimberg; Ze Peng; Ilan Hammel; Ronit Sagi-Eisenberg Early endosomes and a perinuclear, Rab-11-positive compartment have been implicated in the recycling of internalized receptors. In this study, we show that synaptotagmin III (Syt III), a member of the Syt family of proteins, is required...
Journal Articles
J Cell Sci (2002) 115 (15): 3083–3092.
Published: 01 August 2002
...Ze Peng; Elena Grimberg; Ronit Sagi-Eisenberg Downregulation of protein kinase Cα (PKCα) following long-term exposure to phorbol esters such as TPA is traffic dependent and involves delivery of the active, membrane-associated PKCα to endosomes. In this study, we show that synaptotagmin II (Syt II...
Journal Articles
J Cell Sci (2002) 115 (11): 2399–2412.
Published: 01 June 2002
... organelles, some of which are just below the plasma membrane. Total internal reflection fluorescence microscopy shows that NCS-1-EYFP is associated with synaptic-like microvesicles (SLMVs) in growth cones. Overexpression studies show that NCS-1 enhances exocytosis of synaptotagmin-labeled regulated secretory...
Includes: Multimedia, Supplementary data