... focus on the dynamic nature of a conserved chromosomal interface – the synaptonemal complex – and the chromosome movements that accompany meiosis as potential mechanisms to resolve topological constraints. We highlight the advantages of the nematode Caenorhabditis elegans for understanding biophysical...

...Stephen R. Wellard; Karen Schindler; Philip W. Jordan ABSTRACT Precise control of chromosome dynamics during meiosis is critical for fertility. A gametocyte undergoing meiosis coordinates formation of the synaptonemal complex (SC) to promote efficient homologous chromosome recombination. Subsequent...

... of homologues Meiosis Chromatin dynamics Centromere associations Synaptonemal complex Recombination Seventh Framework Programme 10.13039/100011102 FP7/2007-2013 People, Marie Curie Actions 625835 International Atomic Energy Agency https://search.crossref.org...

... males and females. The synaptonemal complex (SC) is a tripartite structure that connects homologous chromosomes in meiosis. Here, aided by super-resolution microscopy techniques, we show that the SC is subject to sexual dimorphism, in mouse germ cells. We have identified a significantly narrower SC...

...Abrahan Hernández-Hernández; Sergej Masich; Tomoyuki Fukuda; Anna Kouznetsova; Sara Sandin; Bertil Daneholt; Christer Höög ABSTRACT The synaptonemal complex transiently stabilizes pairing interactions between homologous chromosomes during meiosis. Assembly of the synaptonemal complex is mediated...

... formation requires the prior synapsis of homologous chromosome axes, which is mediated by the synaptonemal complex, a tripartite proteinaceous structure specific to prophase I of meiosis. Yemanuclein (Yem) is a maternal factor that is crucial for sexual reproduction. It is required in the zygote...

... at the central region of the synaptonemal complex from zygotene until diplotene. During late diplotene both proteins load to the chromocenters, where they colocalize with DNA Topoisomerase IIα, and then accumulate at the inner domain of the centromeres during the first and second meiotic divisions. Interestingly...

...Philip W. Jordan; Jesse Karppinen; Mary A. Handel Summary During meiosis, accurate coordination of the completion of homologous recombination and synaptonemal complex (SC) disassembly during the prophase to metaphase I (G2/MI) transition is essential to avoid aneuploid gametes and infertility...

... condensation Chromosome pairing Synaptonemal complex In meiosis, a single round of DNA replication – the meiotic S phase – precedes two rounds of chromosome segregation, resulting in the production of haploid gametes from diploid cells. The first meiotic division, termed meiosis I, is a crucial stage...

...Geert Hamer; Hong Wang; Ewelina Bolcun-Filas; Howard J. Cooke; Ricardo Benavente; Christer Höög The synaptonemal complex is an elaborate meiosis-specific supramolecular protein assembly that promotes chromosome synapsis and meiotic recombination. We inactivated the meiosis-specific gene Tex12...

... 2007 © The Company of Biologists Limited 2007 2007 Meiosis Cohesin Synaptonemal complex Recombination Accurate segregation of chromosomes during meiosis relies on a number of dynamic changes in chromosome morphology that take place within the context of sister-chromatid cohesion...

...) by the acquisition of RPA, BLM, MSH4 and topoisomerases that function in repair and Holliday junction resolution. At the leptotene-zygotene transition, TNs orient to positions between the aligned cores where they initiate structural interhomolog contacts prior to synaptonemal complex (SC) formation, possibly future...

...Geert Hamer; Katarina Gell; Anna Kouznetsova; Ivana Novak; Ricardo Benavente; Christer Höög During the first meiotic prophase, alignment and synapsis of the homologous chromosomes are mediated by the synaptonemal complex. Incorrect assembly of this complex results in cell death, impaired meiotic...

... or kinetochore assembly in meiosis I of rice. ‡ Authors for correspondence (e-mail: [email protected] ; [email protected] ) * Authors contributed equally to this work 4 10 2005 © The Company of Biologists Limited 2006 2006 Meiosis Synaptonemal complex Homologous...

...Yael Costa; Robert Speed; Rupert Öllinger; Manfred Alsheimer; Colin A. Semple; Philippe Gautier; Klio Maratou; Ivana Novak; Christer Höög; Ricardo Benavente; Howard J. Cooke Completion of meiosis in mammals depends on the formation of the synaptonemal complex, a tripartite structure...

... Meiosis Synaptonemal complex Cohesin complex proteins Sister-chromatid cohesion The generation of haploid germ cells requires a distinct chromosomal segregation process termed meiosis (for a review, see Petronczki et al., 2003 ). Meiosis involves one round of DNA replication followed by one...

...Janet K. Jang; Dalia E. Sherizen; Rajal Bhagat; Elizabeth A. Manheim; Kim S. McKim The relationship between synaptonemal complex formation (synapsis) and double-strand break formation (recombination initiation) differs between organisms. Although double-strand break creation is required for normal...

... it is no longer associated with the chromosomes. Immunogold labelling in conjunction with electron microscopy established that Asy1 localizes to regions of chromatin that associate with the axial/lateral elements of meiotic chromosomes rather than being a component of the synaptonemal complex itself. These data...

... trans-acting factor or factors. Since components of the synaptonemal complex are thought to play a role in centromere cohesion and kinetochore orientation, we evaluated the behavior of the X chromosome at prophase to determine if this factor influenced the propensity of the chromosome for self-synapsis...

... of BLM signals in the synapsed pseudoautosomal region of the X-Y chromosomes, which is a recombinational hot spot, provide indications that BLM protein may function in the meiotic recombination process. REFERENCES Albini , S. M. and Jones , G. H. ( 1988 ). Synaptonemal complex spreading...