...) positively correlate with synaptogenesis. Our subcellular fractionation studies show that the expression of neuropsin and its proteolytic activity on L1CAM are enriched at developing hippocampal synapses. Activation of neuropsin expression upregulates the transcription and cleavage of L1CAM. Furthermore...

.../ Summary: This study shows that the small GTPase TC10 modulates the phosphoinositide-binding-specificity of collybistin, which regulates collybistin trafficking to inhibitory postsynapses and thus affects the assembly of the synaptic gephyrin scaffold. GABA A receptors Synaptogenesis Inhibition...

... described. Integrin activity Autism spectrum disorder Schizophrenia Neurite outgrowth Synaptogenesis Synaptic plasticity Academy of Finland 10.13039/501100002341 European Research Council 10.13039/100010663 Sigrid Juséliuksen Säätiö 10.13039/501100006306...

... homolog SH3PX1 in Drosophila reveals a new role in the development of presynaptic active zones and regulation of neurotransmitter release. Synaptogenesis Neurotransmission Drosophila neuromuscular junction Nervous wreck Sorting nexin Synapse formation and function are crucial...

..., ephrin receptor A (EphA) and Fyn phosphorylate Cdk5 at Tyr15, leading to its activation ( Fig. 1 ), thereby promoting neuronal migration, neurite outgrowth and synaptogenesis ( Zukerberg et al., 2000 ; Sasaki et al., 2002 ; Cheng et al., 2003 ). Abl-mediated phosphorylation of Tyr15 can also...

[email protected] ) 4 01 2013 © 2013. Published by The Company of Biologists Ltd 2013 Synaptogenesis Bouton Neurotransmission Active zone Synaptic vesicle cycle Glutamate receptor Neuromuscular junction Drosophila Lethal Giant Larvae (LGL) was initially characterized...

... Ltd 2012 P bodies Ribonucleoprotein particles Pat1 Synaptogenesis Neuromuscular junction In neurons, the local regulation of mRNA translation is required to control processes ranging from axon guidance and synaptogenesis to the persistent modifications in synaptic efficacy associated...

... specialization to develop at neuromuscular junctions of rapsyn-deficient mice . Nature 377 , 232 - 236 . Gautam M. , Noakes P. G. , Moscoso L. , Rupp F. , Scheller R. H. , Merlie J. P. , Sanes J. R. ( 1996 ). Defective neuromuscular synaptogenesis in agrin-deficient...

... is poorly understood. Here, we examined whether synapsin acts as a physiological effector of MAPK/Erk in synaptogenesis and plasticity. To this aim, we developed an in vitro model of soma-to-soma paired Helix B2 neurons, that establish bidirectional excitatory synapses. We found that the formation...

..., which show a widespread expression, BAD-LAMP expression in mice is confined to the postnatal brain and therein to neuronal subpopulations in layers II/III and V of the neocortex. Onset of expression strictly parallels cortical synaptogenesis. In cortical neurons, the protein is found in defined...

...Yukiko Nakamura; Hideki Tamura; Kazuhiro Horinouchi; Sadao Shiosaka We report that neuropsin is involved in the synaptogenesis/maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway. Most non-synaptic orphan boutons and a number of immature small synaptic boutons...

... contributed equally to this work © The Company of Biologists Limited 2004 2004 Synaptogenesis TGN Transport NCAM Neurons are highly polarized cells. A typical neuron in the central nervous system (CNS) consists of three distinct functional and organizational domains: a cell body (or soma...

... of the differentiation of the postsynaptic membrane in Torpedo electrocytes. 17 08 1996 01 04 1996 © 1996 by Company of Biologists 1996 Agrin Dystrophin Dystroglycan Synaptogenesis Electrocyte Fig. 1. α-Dystroglycan: a high affinity...

... neuromuscular junction synaptogenesis The postsynaptic domain of the neuromuscular junction is characterized by an accumulation of molecules, the prototype of which is the acetylcholine receptor protein (AChR). Several mechanisms have been proposed to account for this local differentiation...

... vesicles. Using immunocytochemistry (laser scanning confocal microscopy, immunoelectron microscopy), fractionation and immunoisolation methods, we show that during the early phase of synaptogenesis, Rab6p is associated with synaptophysin-containing membranes of a trans- Golgi subcompartment, post-Golgi...