... recycle synaptic vesicles during intense activity ( Ferguson et al., 2007 ; Hayashi et al., 2008 ; Lou et al., 2008 ; Armbruster et al., 2013 ). Indeed, synaptic transmission defects limit the average lifespan of dynamin 1 KO mice to less than 2 weeks ( Ferguson et al., 2007 ). Dynamin 2 is expressed...

...Laura E. Perlini; Francesca Botti; Eugenio F. Fornasiero; Maila Giannandrea; Dario Bonanomi; Mario Amendola; Luigi Naldini; Fabio Benfenati; Flavia Valtorta Synapsins are synaptic vesicle (SV)-associated proteins that regulate synaptic transmission and neuronal differentiation. At early stages, Syn...

... previously attributed solely to blocked synaptic-vesicle exocytosis. However, we found that rbo ts displays a strong synergistic interaction with the Syntaxin-1A TS allele syx 3-69 , recently shown to be a dominant positive mutant that increases Syntaxin-1A function. At neuromuscular synapses, rbo ts showed...

.... At later stages, during the onset of synaptogenesis, an intrinsic program of maturation leads to downregulation of basal bulk endocytosis and the emergence of depolarization-induced synaptic-vesicle exo-endocytosis. We propose that the control of bulk membrane retrieval contributes to the homeostatic...

... light on the mechanisms that regulate AP-3 and the trafficking pathways controlled by this adaptor. Phenotypic analysis of organisms carrying genetic deficiencies in the AP-3 pathway highlight its role regulating the targeting of lysosomal, melanosomal and synaptic vesicle-specific membrane proteins...

... deficiencies, in which synaptic vesicle zinc is depleted because the synaptic-vesicle-specific zinc transporter 3 does not reach synaptic vesicles. However, whether zinc transporter 3 is the only membrane protein defining synaptic-vesicle zinc content remains unknown. To address this question, we examined...

...Hideyuki Shimizu; Satoru Kawamura; Koichi Ozaki Rab5 small GTPase is a famous regulator of endocytic vesicular transport from plasma membrane to early endosomes. In neurons, Rab5 is found not only on endocytic vesicles in cell bodies but also on synaptic vesicles in nerve terminals. However...

... progression of synaptic vesicle membranes during their exocytic-endocytic cycle. * e-mail: [email protected]; [email protected] © 2001 by Company of Biologists 2001 Phosphoinositide Synaptic vesicle Neurotransmitter release Clathrin-mediated endocytosis Ca 2...

... © 2000 by Company of Biologists 2000 Synapsin Phosphorylation Cyclic AMP Ca 2+ Synaptic vesicle The presynaptic nerve terminal is a key compartment for communication within the nervous system. In fact, interneuronal communication is achieved primarily via the exocytotic release...

...Eileithyia Swanton; Naomi Bishop; John Sheehan; Stephen High; Philip Woodman ABSTRACT N -ethylmaleimide-sensitive fusion protein (NSF) and its co-factor soluble NSF attachment protein (α-SNAP) are essential components of the synaptic vesicle fusion machinery and form part of a structurally...

...P. Taubenblatt; J. C. Dedieu; T. Gulik-Krzywicki; N. Morel ABSTRACT Synaptic vesicle docking and exocytosis require the specific interaction of synaptic vesicle proteins (such as VAMP/synaptobrevin) with presynaptic plasma membrane proteins (such as syntaxin and SNAP 25). These proteins form...

...) transporter, presumed to be located in the synaptic vesicle membrane. In situ hybridization data in rat brain suggested that it might also take up glycine and thus represent a general Vesicular Inhibitory Amino Acid Transporter (VIAAT). In the present study, we have investigated the localization of VIAAT...

..., and is similarly enriched for synaptic vesicle proteins. As demonstrated by immunoelectron microscopy, myosin-V associates with 30-40% of the vesicles in this population. Although a majority of myosin-V-associated vesicles also label with the synaptic vesicle marker protein, SV2, less than half of the total SV2...

... 1995 by Company of Biologists 1995 targeting transmembrane protein synaptic vesicle cell junction synaptophysin connexin The ordered structure of cells relies on the sorting and assembly of their polypeptide components into specialized membrane-bound compartments. Selective...