...Matheus F. Sathler; Latika Khatri; Jessica P. Roberts; Isabella G. Schmidt; Anastasiya Zaytseva; Regina C. C. Kubrusly; Edward B. Ziff; Seonil Kim ABSTRACT Synaptic strength is altered during synaptic plasticity by controlling the number of AMPA receptors (AMPARs) at excitatory synapses. During...

... synaptic delivery and potentiation. Synaptic plasticity Hippocampus LTP Membrane trafficking Recycling endosomes Ministerio de Ciencia, Innovación y Universidades SAF2015-72988-EXP Joint Programming Initiative A healthy diet for a healthy life 10.13039/100013279 PCIN...

... processes regulating neuronal connectivity – including neurite outgrowth, the formation and maintenance of synapses, and synaptic plasticity – that are affected in neurodevelopmental disorders, such as autism spectrum disorders (ASDs) and schizophrenia. Many ASD- and schizophrenia-associated genes...

... by numerous neurodegenerative disorders associated with post-translational modification of the mitochondrial fission enzyme Drp1. Not surprisingly, mitochondrial dynamics also play an important physiological role in the development of the nervous system and synaptic plasticity. Here, we highlight recent...

.... D. and Goodman , C. S. ( 1996a ). Genetic dissection of structural and functional components of synaptic plasticity. I. Fasciclin II controls synaptic stabilization and growth . Neuron   17 , 641 - 654 . 10.1016/S0896-6273(00)80197-X Schuster , C. M. , Davis , G. W...

...Mónica Fernández-Monreal; Carla Sánchez-Castillo; José A. Esteban ABSTRACT Hippocampal synaptic plasticity involves both membrane trafficking events and intracellular signaling, but how these are coordinated is far from clear. The endosomal transport of glutamate receptors in and out...

...Kristin L. Arendt; Marion Benoist; Argentina Lario; Jonathan E. Draffin; María Muñoz; José A. Esteban ABSTRACT Phosphoinositide 3-kinase (PI3K) and PTEN have been shown to participate in synaptic plasticity during long-term potentiation (LTP) and long-term depression (LTD), respectively...

... Cdk5 p25 p35 β-Amyloid Excitotoxicity Cdk Cyclins Neurodegeneration Alzheimer’s disease Synaptic plasticity Learning and memory Pain signalling Neuronal migration Axonal growth Synaptogenesis Cyclin-dependent kinases (Cdks) are Ser/Thr protein kinases that associate with specific...

...Jun-Young Oh; Ara Kwon; Anna Jo; Hoon Kim; Yong-Sook Goo; Jin-A Lee; Hyong Kyu Kim Summary In neurons, transport of a subset of mRNAs to subcellular regions and their translation has a role in synaptic plasticity. Recent studies have suggested a control mechanism of this local translation through...

... endothelial growth factor (VEGF) and glutamate receptors, and is a common downstream target of several trophic stimuli. Kidins220/ARMS is required for neuronal differentiation and survival, and its expression levels modulate synaptic plasticity. Kidins220/ARMS knockout mice show developmental defects mainly...

.... Acetylcholine receptor Neuromuscular junction Synaptic plasticity © 2012. 2012 14 11 2011 † Author for correspondence ( [email protected] ) * These authors contributed equally to this work ...

.... * These authors contributed equally to this work ‡ Author for correspondence ( [email protected] ) 25 3 2010 © 2010. 2010 Neurotransmitter release Tyrosine kinases Exo-endocytosis Synaptic plasticity Neurotrophins Actin Tyrosine kinases are known to have a key role...

... Drebrin Actin cytoskeleton Synapse development Synaptic plasticity Dendritic spines are the receptive sites of most glutamatergic synapses in adult brains ( Harris and Kater, 1994 ; Hering and Sheng, 2001 ). A typical case of a synaptically functional spine is represented by a mushroom-shaped...

... ) * These authors contributed equally to this work § Present address: MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK 6 11 2008 © The Company of Biologists Limited 2009 2009 Knockout Mouse Hippocampus GluR1 GluR4 Synaptic plasticity The excitatory...

... fluctuate among facilitation, depression and parallel over time. The postsynaptic calmodulin-signaling pathway enhances initial responses and converts this fluctuation to a synaptic depression. We integrated current pulses mathematically based on synaptic plasticity and found that they improve spike...

... Biology and Neuroscience, Istituto Superiore di Sanità, Rome, Italy 26 7 2006 © The Company of Biologists Limited 2006 2006 Synaptic vesicle release Exocytosis Synapsin Synaptic plasticity Cerebellum Transgenic Information transfer between neurons is controlled...

... release of BDNF during physiological synaptic stimulation, and will thereby allow us to elucidate the participation of neurotrophin release in activity dependent synaptic plasticity. * Author for correspondence ( e-mail: [email protected] ) 03 27 1998 14 03 1998...