... that have not been seen in previous studies. These domes developed as a result of ECM swelling via aquaporin water transport activity. Based on computer simulation, uneven swelling, with a positive feedback between cell stretching and enhanced water transport, was a cause of dome formation. These results...

...Yuji Ikegaya; Jeong-Ah Kim; Minami Baba; Takeshi Iwatsubo; Nobuyoshi Nishiyama; Norio Matsuki Postsynaptic neuronal dendrites undergo functional and morphological changes in response to pathologically excessive synaptic activation. Although rapid formation of segmental focal swelling (varicosity...

... of the cells to 10 μ M monensin, which reduces protein secretion by ∼90%, resulted first in the swelling of the trans- Golgi network, then of the trans -most trans- cisterna, the remaining trans- cisternae, and finally of the cis and medial cisternae. We postulate that these different rates of swelling reflect...