... to protein secretion. AMP-activated protein kinase Subcellular localization Golgi Membrane trafficking Protein secretion Wellcome Trust http://dx.doi.org/10.13039/100010269 204766/Z/16/Z Medical Research Council http://dx.doi.org/10.13039/501100007155 University...

... interaction map reveals targets for drug repurposing . Nature 583 , 459 - 468 . 10.1038/s41586-020-2286-9 Gunalan , V. , Mirazimi , A. and Tan , Y. J. ( 2011 ). A putative diacidic motif in the SARS-CoV ORF6 protein influences its subcellular localization and suppression...

... cytoplasmic membrane association of p35–Cdk5 and p39–Cdk5, respectively, through their myristoylation, but it is not clearly understood how the cellular localization is related to different functions. We investigated the role of Cdk5 activity in the subcellular localization of p35–Cdk5 and p39–Cdk5. Cdk5...

... depended on the endogenous claudins of the transfected cells. * Author for correspondence (e-mail: [email protected] ) 24 1 2009 © The Company of Biologists Limited 2009 2009 Kidney Renal cell lines Tight junction Alternative splicing Subcellular localization...

... 2008 © The Company of Biologists Limited 2009 2009 Amyloid precursor protein (APP) Amyloid precursor-like proteins (APLPs) Subcellular localization Cis and trans dimerization APP processing The amyloid beta (A4) precursor protein (APP) involved in Alzheimer's disease belongs...

... 2007 © The Company of Biologists Limited 2008 2008 PTEN Nuclear Subcellular localization Cowden PHTS Bifurcation Phosphatase and tensin homolog (mutated in multiple advanced cancers 1) ( PTEN ), located on 10q23.3, encodes a 403-residue dual-specificity phosphatase that has...

... and translation. Here, we report that the ETR-3 protein contains multiple regions that control its subcellular localization and are important for its activity as a splicing regulator. We cloned ETR-3 from chicken heart and fused it to the C terminus of green fluorescent protein (GFPcETR3vL). GFPcETR3vL is found...

... between subtype binding and the subcellular localization of CDC25B. All three subtypes were found to bind to CDC25B. Site-directed mutagenesis studies revealed that 14-3-3β bound exclusively near serine-309 of CDC25B1, which is within a potential consensus motif for 14-3-3 binding. By contrast, 14-3-3σ...

...Ziv Raviv; Eyal Kalie; Rony Seger The ERK5 signaling cascade acts through sequential activation of MEKK2/3, MEK5 and ERK5 and transmits signals to a variety of stress and mitogenic related targets. In this study we examined the subcellular localization of the components of the ERK5 cascade...

... in dimerization. Second, the subcellular localization of the wild-type (WT) protein and mutants was analyzed by specific immunodetection and confocal microscopy. Most of the mutants were cytoplasmic like Hsp90WT, a nuclear localization being barely detectable in the WT protein or in mutants with a C-terminal...

... rab protein epithelial cell subcellular localization During the past years, genetic and biochemical evidence has demonstrated that small GTPases of the Ypt1/Sec4/rab family are essential regulatory elements of vesicular transport in eukaryotic cells (reviewed by Goud and McCaffrey, 1991...

...-related GTP-binding protein from platelets . Proc. Nat. Acad. Sci. USA 87 , 6527 – 6531 . 10.1073/pnas.87.17.6527 Olkkonen , V. , Dupree , P. , Killisch , I. , Lütcke , A. , Zerial , M. and Simons , K. ( 1993 ). Molecular cloning and subcellular localization...