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Keywords: Stress response
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Journal Articles
J Cell Sci (2020) 133 (13): jcs245589.
Published: 09 July 2020
.../ Highlighted Article: Mitochondrial positioning, ROS levels and the hypoxia response pathway are involved in the activation of the HSF1-mediated heat shock response pathway in mammals. Hypoxia response Oxidative stress Stress response Chaperones Transcriptional regulation Mitochondrial transport...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (21): jcs238402.
Published: 01 November 2019
... to the regulation of the cell cycle, transcription and metabolism. Induction of transcription is mediated through the activation of stress-responsive transcription factors that facilitate the release of stalled RNA polymerase II and so allow for transcriptional elongation. Repression of transcription, in turn...
Journal Articles
J Cell Sci (2018) 131 (4): jcs202002.
Published: 14 February 2018
... LCDs and localize to stress-induced liquid-like compartments. Consequently, gene silencing through miRNAs and alternative splicing of pre-mRNAs are emerging as crucial post-transcriptional mechanisms that function on a genome-wide scale to regulate the cellular stress response. In this Review, we...
Journal Articles
J Cell Sci (2017) 130 (5): 927–937.
Published: 01 March 2017
... to cell survival. Haploid cell Translational control Stress response Stress granules Translation initiation eIF2α The second stress-sensitive mechanism of translation initiation involves the assembly of the eIF4F (i.e. eIF4E–eIF4G–eIF4A) complex that recognizes the cap (m 7 GTP...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (12): 2317–2328.
Published: 15 June 2016
... kinase JNK family by IRE1α late in the ER stress response promotes apoptosis. Here, we show that activation of JNK in the ER stress response precedes activation of XBP1. This activation of JNK is dependent on IRE1α and TRAF2 and coincides with JNK-dependent induction of expression of several...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (9): 1762–1772.
Published: 01 May 2015
.../by/3.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Unfolded protein response Stress response Endoplasmic reticulum Intrinsically disordered region Molecular chaperone Misfolded protein...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (18): 4078–4088.
Published: 15 September 2014
... in any medium provided that the original work is properly attributed. Endoplasmic reticulum Stress response Autophagy Autophagy is the transport of cytoplasmic constituents into lysosomes. Cells utilize this versatile process for many purposes, including the non-selective breakdown...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (9): 1992–2004.
Published: 01 May 2014
... mRNA metabolism Endoplasmic reticulum Translation Saccharomyces cerevisiae mRNA-binding proteins mRNA decay Stress response Ribonucleotide particles Stress granules © 2014. Published by The Company of Biologists Ltd 2014 2 09 2013 4 02 2014 Competing interests...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (14): 3010–3020.
Published: 15 July 2013
... , 214 – 229 . 10.1091/mbc.E02-08-0499 Chen   D. , Wilkinson   C. R. , Watt   S. , Penkett   C. J. , Toone   W. M. , Jones   N. , Bähler   J. ( 2008 ). Multiple pathways differentially regulate global oxidative stress responses in fission yeast.   Mol. Biol. Cell   19...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (12): 2668–2677.
Published: 15 June 2013
... in the absence of Chs1, demonstrating that fungi have previously unsuspected redundant strategies to enable septation and cell division to be maintained, even under potentially lethal environmental conditions. Chitin Cytokinesis Fungal cell wall Septum Signal transduction Stress response In fungi...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (14): 3333–3342.
Published: 15 July 2012
...Amit Sadeh; Dror Baran; Misha Volokh; Amir Aharoni Summary The Msn2 and Msn4 transcription factors play crucial roles in the yeast general stress response. Previous studies identified several large functional domains of Msn2, mainly through crude truncations. Here, using bioinformatics...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (23): 4087–4095.
Published: 01 December 2011
... excellent hybridization kinetics in living cells ( Okabe et al., 2011 ; Molenaar et al., 2001 ). Using this kind of probe, we directly visualized endogenous mRNAs in living cells and monitored the localization of mRNAs during the stress response in real time. Furthermore, we performed FRAP and inverse FRAP...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (17): 3006–3016.
Published: 01 September 2011
...-regulated gene induction through NR4As appears to function in the dopamine synthesis pathway and may be involved in immune and stress responses. * These authors contributed equally to this work ‡ Author for correspondence ( takeda@mol.f.u-tokyo.ac.jp ) 3 5 2011 © 2011. 2011...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (13): 2277–2286.
Published: 01 July 2011
... of laforin and malin. This study demonstrates that laforin and malin are key regulators of HSF1 and that defects in the HSF1-mediated stress response pathway might underlie some of the pathological symptoms in LD. The activation of HSF1 involves its heat-shock-induced hyperphosphorylation and its...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (11): 1943–1951.
Published: 01 June 2011
.... ‡ These authors contributed equally to this work § Author for correspondence ( muller@ipbs.fr ) 14 2 2011 © 2011. 2011 DNA repair DNA-PK Hypoxia Stress response Hypoxic stress has a pivotal role in normal human development and physiology, including embryogenesis and wound repair...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (20): 3558–3565.
Published: 15 October 2010
.... K. , Allen A. E. , Sivaprasad U. ( 1999 ). ATF3 and stress responses . Gene Expr. 7 , 321 - 335 . Hai T. , Lu D. , Wolford C. C. ( 2006 ). Transcription factors: ATF . In Encyclopedia of Respiratory Medicine , Vol. 4 (ed. Laurent G. J. , Shaprio S...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (12): 2124–2134.
Published: 15 June 2010
... and numr-2 transcription in pharyngeal and intestinal cells. Other environmental stressors do not affect transcription, indicating that these are metal-specific, stress-responsive genes. NUMR-1 and NUMR-2 target to nuclei and colocalize with HSF-1, suggesting that they may be components of nuclear stress...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (20): 3619–3626.
Published: 15 October 2009
... structurally distinct and do not interdigitate. ‡ Authors for correspondence ( weil@vjf.cnrs.fr ; pierron@vjf.cnrs.fr ) * These authors contributed equally to this work 1 8 2009 © The Company of Biologists Limited 2009 2009 Stress response mRNA storage mRNA degradation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (24): 4055–4068.
Published: 15 December 2008
...Alasdair M. Robertson; Iain M. Hagan The cell-integrity and stress-response MAP kinase pathways (CIP and SRP, respectively) are stimulated by various environmental stresses. Ssp1 kinase modulates actin dynamics and is rapidly recruited to the plasma membrane following osmotic stress. Here, we show...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2008) 121 (6): 825–833.
Published: 15 March 2008
... filaments against disruption in a chaperone-like fashion. * Author for correspondence (e-mail: gerhard.wiche@univie.ac.at ) 17 12 2007 © The Company of Biologists Limited 2008 2008 Epiplakin Hyperphosphorylation Keratin Spectraplakin Stress response Epiplakin...