...Xiaoyan Zhai; Haibo Du; Yuxin Shen; Xiujuan Zhang; Zhengjun Chen; Yanfei Wang; Zhigang Xu ABSTRACT Stereocilia are F-actin-based protrusions on the apical surface of inner-ear hair cells and are indispensable for hearing and balance perception. The stereocilia of each hair cell are organized...

... and the early development of HCs, as nascent HCs in Lbh knockout mice had normal looking stereocilia. The stereocilia bundle was mechanosensitive and OHCs exhibited the characteristic electromotility. However, Lbh -null mice displayed progressive hearing loss, with stereocilia bundle degeneration and OHC loss...

...Thaher Pelaseyed; Anthony Bretscher ABSTRACT Cells of transporting epithelia are characterized by the presence of abundant F-actin-based microvilli on their apical surfaces. Likewise, auditory hair cells have highly reproducible rows of apical stereocilia (giant microvilli) that convert mechanical...

... possessing highly elaborate stable actin protrusions (stereocilia). Hair cells of Atoh1–Cre;Cdc42 flox/flox mice developed normally but progressively degenerated after maturation, resulting in progressive hearing loss particularly at high frequencies. Cochlear hair cell degeneration was more robust in inner...

...Lili Zheng; Dina M. Beeler; James R. Bartles ABSTRACT The espin actin-bundling proteins, which are produced as isoforms of different sizes from a single gene, are required for the growth of hair cell stereocilia. We have characterized an additional actin-filament-binding site present...

... the channel gate is located. Proteins known to be present in the lower tip link dense plaques are also listed (some of these such as harmonin-b and MAGUK are in involved in development of the stereocilia). The evidence suggesting that the tip link is composed of two homodimers of PCDH15 and CDH23...

... to form the vestibulocochlear ganglion and in hair cells that possess mechanosensory stereocilia. Knockdown of Xevl perturbs epithelial morphology and intercellular adhesion in the otic vesicle and disrupts formation of the vestibulocochlear ganglion, evidenced by reduction of ganglion size...

...M'hamed Grati; Nisha Aggarwal; Emanuel E. Strehler; Robert J. Wenthold The plasma membrane Ca 2+ -ATPase-2 (PMCA2) is expressed in stereocilia of hair cells of the inner ear, whereas PMCA1 is expressed in the basolateral plasma membrane of hair cells. Both extrude excess Ca 2+ from the cytosol...