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Keywords: Stereocilia
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Journal Articles
In collection:
Mechanobiology
J Cell Sci (2021) 134 (7): jcs254458.
Published: 13 April 2021
... and the early development of HCs, as nascent HCs in Lbh knockout mice had normal looking stereocilia. The stereocilia bundle was mechanosensitive and OHCs exhibited the characteristic electromotility. However, Lbh -null mice displayed progressive hearing loss, with stereocilia bundle degeneration and OHC loss...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2018) 131 (20): jcs221853.
Published: 17 October 2018
...Thaher Pelaseyed; Anthony Bretscher ABSTRACT Cells of transporting epithelia are characterized by the presence of abundant F-actin-based microvilli on their apical surfaces. Likewise, auditory hair cells have highly reproducible rows of apical stereocilia (giant microvilli) that convert mechanical...
Journal Articles
J Cell Sci (2014) 127 (9): 2040–2052.
Published: 01 May 2014
... possessing highly elaborate stable actin protrusions (stereocilia). Hair cells of Atoh1–Cre;Cdc42 flox/flox mice developed normally but progressively degenerated after maturation, resulting in progressive hearing loss particularly at high frequencies. Cochlear hair cell degeneration was more robust in inner...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (6): 1306–1317.
Published: 15 March 2014
...Lili Zheng; Dina M. Beeler; James R. Bartles ABSTRACT The espin actin-bundling proteins, which are produced as isoforms of different sizes from a single gene, are required for the growth of hair cell stereocilia. We have characterized an additional actin-filament-binding site present...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (8): 1721–1731.
Published: 15 April 2013
... . 10.1113/jphysiol.2004.065565 Belyantseva   I. A. , Boger   E. T. , Friedman   T. B. ( 2003 ). Myosin XVa localizes to the tips of inner ear sensory cell stereocilia and is essential for staircase formation of the hair bundle.   Proc. Natl. Acad. Sci. USA   100 , 13958 – 13963 . 10.1073...
Journal Articles
J Cell Sci (2007) 120 (15): 2641–2651.
Published: 01 August 2007
... to form the vestibulocochlear ganglion and in hair cells that possess mechanosensory stereocilia. Knockdown of Xevl perturbs epithelial morphology and intercellular adhesion in the otic vesicle and disrupts formation of the vestibulocochlear ganglion, evidenced by reduction of ganglion size...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (14): 2995–3007.
Published: 15 July 2006
...M'hamed Grati; Nisha Aggarwal; Emanuel E. Strehler; Robert J. Wenthold The plasma membrane Ca 2+ -ATPase-2 (PMCA2) is expressed in stereocilia of hair cells of the inner ear, whereas PMCA1 is expressed in the basolateral plasma membrane of hair cells. Both extrude excess Ca 2+ from the cytosol...
Includes: Multimedia, Supplementary data