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Keywords: Stem cells
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Journal Articles
J Cell Sci jcs.258901.
Published: 26 October 2021
... (APOA1) was associated with an increase in the Lin(-)Sca-1(+)Kit(+) bone marrow stem cell population and lymphoid primed multipotent progenitor numbers, which translated into a higher production and systemic flux of T cell subsets. In accordance with APOA1 deficiency-associated priming of stem cells...
Journal Articles
In collection:
Stem Cells
J Cell Sci (2020) 133 (12): jcs242297.
Published: 19 June 2020
... the questions raised above. * Present address: Developmental and Stem Cell Biology Division, Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia. § Present address: Fundación Ciencia & Vida, 7780272 Santiago, Chile. ¶ Authors for correspondence ( oicontre@uc.cl...
Includes: Supplementary data
Journal Articles
In collection:
Metabolism
J Cell Sci (2020) 133 (10): jcs239467.
Published: 27 May 2020
... consumption. Furthermore, Smed-Sirt-1(RNAi) animals displayed reduced cell death and increased stem cell proliferation accompanied by impaired expression of intestinal lineage progenitors and reduced branching of the gut. Taken together, our findings indicate that Sirtuin-1 is a crucial metabolic hub capable...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (19): jcs230607.
Published: 09 October 2019
.... Published by The Company of Biologists Ltd 2019 http://www.biologists.com/user-licence-1-1/ Summary: This study reveals a stepwise process of basal-type lumenogenesis by extraembryonic endoderm stem cells in vitro and proposes a physiological interpretation. Stem cells Visceral...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (16): jcs230276.
Published: 15 August 2019
..., the central pathology of cardiovascular disease. Stem cell technology will revolutionise regenerative medicine, but a need remains to understand key mechanisms of vascular differentiation. RNA-binding proteins have emerged as novel post-transcriptional regulators of alternative splicing and we have previously...
Includes: Supplementary data
Journal Articles
In collection:
Stem Cells
J Cell Sci (2019) 132 (13): jcs225946.
Published: 05 July 2019
... factors to direct expression of crucial muscle regulatory genes and contribute to the control of skeletal myogenesis. VGLL3 TEAD YAP TAZ WWTR1 Skeletal muscle Stem cells The Hippo signal transduction network regulates development, stem cell identity and function, cell proliferation...
Includes: Supplementary data
Journal Articles
In collection:
Stem Cells
J Cell Sci (2017) 130 (12): 2018–2025.
Published: 15 June 2017
... known as ESR1) and/or AREG signaling were necessary for non-mammary cell redirection, we inoculated either ERα −/− or AREG −/− mammary cells with non-mammary progenitor cells (WAP-Cre/Rosa26LacZ+ male testicular cells or GFP-positive embryonic neuronal stem cells). ERα −/− cells possessed a limited...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (20): 3816–3831.
Published: 15 October 2016
..., DUX4 expression results in maintenance of a stem-cell-like and less-differentiated state, with concomitant suppression of proliferation and inhibition of differentiation. This striking differentiation defect might explain the lack of muscle phenotype in our D4Z4-2.5 mice because rare DUX4-expressing...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (21): 4543–4548.
Published: 01 November 2014
...Yu Xin Wang; Nicolas A. Dumont; Michael A. Rudnicki ABSTRACT Muscle stem cells facilitate the long-term regenerative capacity of skeletal muscle. This self-renewing population of satellite cells has only recently been defined through genetic and transplantation experiments. Although muscle stem...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (24): 5610–5625.
Published: 15 December 2013
.... K. , Germain   S. , Chretien   F. , Sotiropoulos   A.   ( 2009 ). Autocrine and paracrine angiopoietin 1/Tie-2 signaling promotes muscle satellite cell self-renewal.   Cell Stem Cell   5 , 298 – 309 . 10.1016/j.stem.2009.06.001 Agley   C. C. , Velloso   C. P. , Lazarus...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (18): 4069–4076.
Published: 15 September 2013
...Swathi Yadlapalli; Yukiko M. Yamashita Summary The immortal strand hypothesis proposes that stem cells retain a template copy of genomic DNA (i.e. an ‘immortal strand’) to avoid replication-induced mutations. An alternative hypothesis suggests that certain cells segregate sister chromatids non...
Journal Articles
J Cell Sci (2013) 126 (14): 3192–3203.
Published: 15 July 2013
... together, Nanos was shown previously to have a conserved role in germ stem cell maintenance, self-renewal, migration, and prevention of differentiation. Our data add a similar role for Nanos in a neural lineage, and suggest it has no direct role in cnidarian axis patterning, a role that might be an insect...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (23): 5609–5620.
Published: 01 December 2012
...Yu Zhang; Wenlin Li; Timothy Laurent; Sheng Ding Summary Despite the great potential of stem cells for basic research and clinical applications, obstacles – such as their scarce availability and difficulty in controlling their fate – need to be addressed to fully realize their potential. Recent...
Journal Articles
In collection:
Metabolism
J Cell Sci (2012) 125 (23): 5597–5608.
Published: 01 December 2012
...Victoria A. Rafalski; Elena Mancini; Anne Brunet Summary Metabolism is influenced by age, food intake, and conditions such as diabetes and obesity. How do physiological or pathological metabolic changes influence stem cells, which are crucial for tissue homeostasis? This Commentary reviews recent...
Journal Articles
J Cell Sci (2012) 125 (13): 3061–3073.
Published: 01 July 2012
...Akiko Mammoto; Tadanori Mammoto; Donald E. Ingber Summary Transcriptional regulation contributes to the maintenance of pluripotency, self-renewal and differentiation in embryonic cells and in stem cells. Therefore, control of gene expression at the level of transcription is crucial for embryonic...
Journal Articles
J Cell Sci (2012) 125 (7): 1657–1665.
Published: 01 April 2012
... throughout the body. Here, we use the planarian model system to address TOR regulation at the organismal level. The planarian TOR homolog ( Smed-TOR ) is ubiquitously expressed, including stem cells (neoblasts) and differentiated tissues. Inhibition of TOR with RNA interference severely restricts cell...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (5): 1274–1283.
Published: 01 March 2012
...Sriram Bandi; Kang Cheng; Brigid Joseph; Sanjeev Gupta Understanding the identity of lineage-specific cells arising during manipulations of stem cells is necessary for developing their potential applications. For instance, replacement of crucial functions in organ failure by transplantation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (14): 2357–2366.
Published: 15 July 2011
...Jonathan R. Yeh; Xiangfan Zhang; Makoto C. Nagano The maintenance of spermatogonial stem cells (SSCs) provides the foundation for life-long spermatogenesis. Although glial-cell-line-derived neurotrophic factor and fibroblast growth factor 2 are crucial for self-renewal of SSCs, recent studies have...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (11): 1775–1783.
Published: 01 June 2011
..., the miRNA pathway has emerged as one of the most extensively investigated pathways of the past decade. Because of their potential to regulate a large number of protein-encoding genes, miRNAs have been implicated in numerous biological processes, including development, stem cell regulation and human diseases...
Journal Articles
J Cell Sci (2011) 124 (6): 933–939.
Published: 15 March 2011
...Swathi Yadlapalli; Jun Cheng; Yukiko M. Yamashita Adult stem cells continuously supply differentiated cells throughout the life of organisms. This increases the risk of replicative senescence or neoplastic transformation due to mutations that accumulate over many rounds of DNA replication...