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Keywords: Stem cells
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Journal Articles
J Cell Sci (2022) 135 (10): jcs259329.
Published: 20 May 2022
... Comma-1D cells can be used as an experimental model to study both the differentiation and the transformation processes in vitro . Comma-1D Mammary epithelium differentiation Stem cells Oncogenesis Breast cancer National Institutes of Health http://dx.doi.org/10.13039/100000002...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (9): jcs259304.
Published: 13 May 2022
... application of electric stimulation enables cellular plasticity and the re-establishment of stem cell activity in tissues damaged by ionizing radiation. We show that subthreshold direct current stimulation (DCS) rapidly restores pluripotent stem cell populations previously eliminated by lethally γ-irradiated...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (5): jcs258901.
Published: 16 November 2021
...-derived apolipoprotein A1 (APOA1) was associated with an increase in the Lin − Sca-1 + Kit + (LSK) bone marrow stem cell population and lymphoid-primed multipotent progenitor numbers, which translated into a higher production and systemic flux of T cell subsets. In accordance with APOA1 deficiency...
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Stem Cells
J Cell Sci (2020) 133 (12): jcs242297.
Published: 19 June 2020
.... Myofibroblasts Stem cells Regeneration MSCs PDGFRα Myoblasts The remarkable long-term capacity of adult skeletal muscle to grow and regenerate is largely based on the presence of tissue-resident muscle stem cells (MuSCs, formerly called satellite cells) ( Lepper et al., 2011 ; Murphy et al., 2011...
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Metabolism
J Cell Sci (2020) 133 (10): jcs239467.
Published: 27 May 2020
... consumption. Furthermore, Smed-Sirt-1(RNAi) animals displayed reduced cell death and increased stem cell proliferation accompanied by impaired expression of intestinal lineage progenitors and reduced branching of the gut. Taken together, our findings indicate that Sirtuin-1 is a crucial metabolic hub capable...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (19): jcs230607.
Published: 9 October 2019
..., but not in fibroblasts or embryonic stem cells (ESCs) ( Fig. S1C ). Vacuoles were also easily induced in pXEN-like cell lines established from rat and mouse yolk sacs, in primary pXEN cells emerging from cultured rat blastocysts and (less efficiently) in primary cultures of dissociated rat and mouse yolk sacs ( Fig. S1C...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (16): jcs230276.
Published: 15 August 2019
..., the central pathology of cardiovascular disease. Stem cell technology will revolutionise regenerative medicine, but a need remains to understand key mechanisms of vascular differentiation. RNA-binding proteins have emerged as novel post-transcriptional regulators of alternative splicing and we have previously...
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Journal Articles
In collection:
Stem Cells
J Cell Sci (2019) 132 (13): jcs225946.
Published: 5 July 2019
... to the control of skeletal myogenesis. VGLL3 TEAD YAP TAZ WWTR1 Skeletal muscle Stem cells The Hippo signal transduction network regulates development, stem cell identity and function, cell proliferation, and organ and body size ( Hansen et al., 2015 ; Piccolo et al., 2014 ; Tremblay...
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Journal Articles
In collection:
Stem Cells
J Cell Sci (2017) 130 (12): 2018–2025.
Published: 15 June 2017
... known as ESR1) and/or AREG signaling were necessary for non-mammary cell redirection, we inoculated either ERα −/− or AREG −/− mammary cells with non-mammary progenitor cells (WAP-Cre/Rosa26LacZ+ male testicular cells or GFP-positive embryonic neuronal stem cells). ERα −/− cells possessed a limited...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (20): 3816–3831.
Published: 15 October 2016
.... DUX4 acts mainly as a transcriptional activator that inhibits myogenesis by orchestrating a gene expression profile representative of a more stem-cell-like state. DUX4 DUX4c FSHD Stem cells Skeletal muscle Satellite cell Transcriptome Facioscapulohumeral muscular dystrophy (FSHD...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (21): 4543–4548.
Published: 1 November 2014
...Yu Xin Wang; Nicolas A. Dumont; Michael A. Rudnicki ABSTRACT Muscle stem cells facilitate the long-term regenerative capacity of skeletal muscle. This self-renewing population of satellite cells has only recently been defined through genetic and transplantation experiments. Although muscle stem...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (24): 5610–5625.
Published: 15 December 2013
.... , Authier   F-J. , Rudnicki   M. A. , Gherardi   R. K. , Germain   S. , Chretien   F. , Sotiropoulos   A.   ( 2009 ). Autocrine and paracrine angiopoietin 1/Tie-2 signaling promotes muscle satellite cell self-renewal.   Cell Stem Cell   5 , 298 – 309 . 10.1016/j.stem.2009.06.001...
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Journal Articles
J Cell Sci (2013) 126 (18): 4069–4076.
Published: 15 September 2013
...Swathi Yadlapalli; Yukiko M. Yamashita Summary The immortal strand hypothesis proposes that stem cells retain a template copy of genomic DNA (i.e. an ‘immortal strand’) to avoid replication-induced mutations. An alternative hypothesis suggests that certain cells segregate sister chromatids non...
Journal Articles
J Cell Sci (2013) 126 (14): 3192–3203.
Published: 15 July 2013
... but suppresses aboral structures in Hydractinia metamorphosis and regeneration.   Development   137 , 3057 – 3066 . 10.1242/dev.046631 Duffy   D. J. , Millane   R. C. , Frank   U. ( 2012 ). A heat shock protein and Wnt signaling crosstalk during axial patterning and stem cell proliferation...
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Journal Articles
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Metabolism
J Cell Sci (2012) 125 (23): 5597–5608.
Published: 1 December 2012
...Victoria A. Rafalski; Elena Mancini; Anne Brunet Summary Metabolism is influenced by age, food intake, and conditions such as diabetes and obesity. How do physiological or pathological metabolic changes influence stem cells, which are crucial for tissue homeostasis? This Commentary reviews recent...
Journal Articles
J Cell Sci (2012) 125 (23): 5609–5620.
Published: 1 December 2012
...Yu Zhang; Wenlin Li; Timothy Laurent; Sheng Ding Summary Despite the great potential of stem cells for basic research and clinical applications, obstacles – such as their scarce availability and difficulty in controlling their fate – need to be addressed to fully realize their potential. Recent...
Journal Articles
J Cell Sci (2012) 125 (13): 3061–3073.
Published: 1 July 2012
...Akiko Mammoto; Tadanori Mammoto; Donald E. Ingber Summary Transcriptional regulation contributes to the maintenance of pluripotency, self-renewal and differentiation in embryonic cells and in stem cells. Therefore, control of gene expression at the level of transcription is crucial for embryonic...
Journal Articles
J Cell Sci (2012) 125 (7): 1657–1665.
Published: 1 April 2012
... throughout the body. Here, we use the planarian model system to address TOR regulation at the organismal level. The planarian TOR homolog ( Smed-TOR ) is ubiquitously expressed, including stem cells (neoblasts) and differentiated tissues. Inhibition of TOR with RNA interference severely restricts cell...
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Journal Articles
J Cell Sci (2012) 125 (5): 1274–1283.
Published: 1 March 2012
...Sriram Bandi; Kang Cheng; Brigid Joseph; Sanjeev Gupta Understanding the identity of lineage-specific cells arising during manipulations of stem cells is necessary for developing their potential applications. For instance, replacement of crucial functions in organ failure by transplantation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (14): 2357–2366.
Published: 15 July 2011
...Jonathan R. Yeh; Xiangfan Zhang; Makoto C. Nagano The maintenance of spermatogonial stem cells (SSCs) provides the foundation for life-long spermatogenesis. Although glial-cell-line-derived neurotrophic factor and fibroblast growth factor 2 are crucial for self-renewal of SSCs, recent studies have...
Includes: Supplementary data