... lifespan and are continuously replaced from a common stem cell niche. Using a combination of single-cell RNA sequencing data, immunofluorescence staining and lineage tracing, we identified CXCR4 expression in proliferative stem cells and the basal neuronal lineage. Mice with a conditional knockout of Cxcr4...

...Rhiannon R. Penkert; Bryce LaFoya; Lucille Moholt-Siebert; Elizabeth Vargas; Sarah E. Welch; Kenneth E. Prehoda ABSTRACT Drosophila neural stem cells, or neuroblasts, rapidly proliferate during embryonic and larval development to populate the central nervous system. Neuroblasts divide...

...Tanja Müller; Marina Reichlmeir; Ann-Christin Hau; Ilka Wittig; Dorothea Schulte ABSTRACT Tight control over transcription factor activity is necessary for a sensible balance between cellular proliferation and differentiation in the embryo and during tissue homeostasis by adult stem cells...

... comprise heterogeneous populations of stem and differentiated cells. Here, we examine Ca 2+ dynamics in the adult Drosophila intestine, a self-renewing epithelial organ in which stem cells continuously produce daughters that differentiate into either enteroendocrine cells or enterocytes. Live imaging...

... of xenophagy in macrophages targets Mtb to autophagosomes; however, how Mtb is targeted to autophagosomes in human macrophages at a high spatial and temporal resolution is unknown. Here, we use human induced pluripotent stem cell-derived macrophages (iPSDMs) to study the human macrophage response to Mtb...

...Annelies Wouters; Jan-Pieter Ploem; Sabine A. S. Langie; Tom Artois; Aziz Aboobaker; Karen Smeets ABSTRACT Pluripotent stem cells hold great potential for regenerative medicine. Increased replication and division, such is the case during regeneration, concomitantly increases the risk of adverse...

... signaling and polarity proteins. Arabidopsis Asymmetric cell division SPEECHLESS Cell–cell signaling Stem cell Stomata National Institutes of Health 10.13039/100000002 NIH5T32GM007276 Howard Hughes Medical Institute 10.13039/100000011 Stomata are pores...

... complex that comprises ERF and transcription factors of the GRAS domain type. This interaction turns ERFs into highly potent and stress-responsive activators of cell proliferation. The potency to induce stem cell identity suggests that these heterodimeric transcription factor complexes could become...

...Fidel Lozano-Elena; Ainoa Planas-Riverola; Josep Vilarrasa-Blasi; Rebecca Schwab; Ana I. Caño-Delgado; Jenny Russinova ABSTRACT Stem cell regeneration is crucial for both cell turnover and tissue healing in multicellular organisms. In Arabidopsis roots, a reduced group of cells known...

...-long actin-rich filopodia, termed cytonemes, provides one mechanism for this spatiotemporal regulation of extracellular cues. We provide here a mechanism whereby the stem-cell marker Lgr5, and its family member Lgr4, promote the formation of cytonemes. Lgr4- and Lgr5-induced cytonemes exceed lengths...

...Takashi Nakamura; Yasuo Yoshitomi; Kiyoshi Sakai; Vyomesh Patel; Satoshi Fukumoto; Yoshihiko Yamada ABSTRACT The basal layer of the epidermis contains stem cells and transit amplifying cells that rapidly proliferate and differentiate further into the upper layers of the epidermis. A number...

...Robert Y. L. Tsai ABSTRACT A quintessential trait of stem cells is embedded in their ability to self-renew without incurring DNA damage as a result of genome replication. One key self-renewal factor is the nucleolar GTP-binding protein nucleostemin (also known as guanine-nucleotide-binding protein...

...Xiaoyan Liao; Haipeng Xue; Yu-Chieh Wang; Kristopher L. Nazor; Shuren Guo; Neha Trivedi; Suzanne E. Peterson; Ying Liu; Jeanne F. Loring; Louise C. Laurent Summary The differentiation of human pluripotent stem cells (hPSCs) to insulin-expressing beta islet-like cells is a promising in vitro model...

... of transcription factors maintains stem cell properties in both normal and malignant tissues; however, the underlying molecular pathway involved in this process has not been completely defined. Using a microRNA microarray screening assay, we identified let-7 miRNAs as downstream targets of the Wnt–β-catenin...

...Barbara Gayraud-Morel; Fabrice Chrétien; Aurélie Jory; Ramkumar Sambasivan; Elisa Negroni; Patricia Flamant; Guillaume Soubigou; Jean-Yves Coppée; James Di Santo; Ana Cumano; Vincent Mouly; Shahragim Tajbakhsh Skeletal muscle stem cell fate in adult mice is regulated by crucial transcription...

... glucocorticoid and WNT signalling pathways. 28 9 2010 © 2011. 2011 Dexamethasone Stem cell Reprogramming LY294002 Liver Pancreas Transdifferentiation is a form of metaplasia and describes the irreversible switching of cellular differentiation in fully differentiated cells ( Burke...

... to cell within the brains of afflicted individuals, thereby spreading the specific neurodegenerative phenotypes distinctive to the protein being converted to amyloid. Importantly, this transmissibility mandates a re-evaluation of emerging neuronal graft and stem-cell therapies. In this Commentary, we...

...Chien-Chia Cheng; Der-Yuan Wang; Ming-Hui Kao; Jan-Kan Chen Corneal epithelial stem cells are thought to reside in the limbus, the transition zoon between cornea and conjunctiva. Keratinocyte growth factor (KGF) and hepatocyte growth factor (HGF) are two paracrine factors that regulate...

...Yusuke Ono; Viola F. Gnocchi; Peter S. Zammit; Ryoichi Nagatomi Muscle satellite cells are the resident stem cells of adult skeletal muscle. Here, we have examined the role of the multifunctional protein presenilin-1 (PS1) in satellite cell function. PS1 acts as a crucial component of the γ...

...-cell contact. 24 10 2008 © The Company of Biologists Limited 2009 2009 Cell-cell communication Intercellular transfer Membrane fusion Stem cell Living tissues are increasingly seen as exceptionally intricate, well-structured collections of cells embedded in dynamically...